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Characterization of Femtosecond Laser and Porcine Crystalline Lens Interactions by Optical Microscopy

Micromachines (Basel), 2022-12, Vol.13 (12), p.2128 [Peer Reviewed Journal]

COPYRIGHT 2022 MDPI AG ;2022 by the authors. 2022 ;ISSN: 2072-666X ;EISSN: 2072-666X ;DOI: 10.3390/mi13122128 ;PMID: 36557426

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  • Title:
    Characterization of Femtosecond Laser and Porcine Crystalline Lens Interactions by Optical Microscopy
  • Author: Ben Moussa, Olfa ; Talbi, Abderazek ; Poinard, Sylvain ; Garcin, Thibaud ; Gauthier, Anne-Sophie ; Thuret, Gilles ; Gain, Philippe ; Maurer, Aurélien ; Sedao, Xxx ; Mauclair, Cyril
  • Subjects: Care and treatment ; Cataract ; cavitation ; crystalline lens ; histology ; Microscope and microscopy ; Surgery ; time-resolved imagining ; ultrafast laser
  • Is Part Of: Micromachines (Basel), 2022-12, Vol.13 (12), p.2128
  • Description: The use of ultrafast laser pulses for eye anterior segment surgery has seen a tremendous growth of interest as the technique has revolutionized the field, from the treatment of myopia, hyperopia, and presbyopia in the cornea to laser-assisted cataract surgery of the crystalline lens. For the latter, a comprehensive understanding of the laser-tissue interaction has yet to be achieved, mainly because of the challenge of observing the interaction zone in situ with sufficient spatial and temporal resolution in the complex and multi-layered tissue of the crystalline lens. We report here on the dedicated characterization results of the laser-tissue interaction zone in the ex vivo porcine lens using three different methods: in situ and real-time microscopy, wide-field optical imaging, and phase-contrast microscopy of the histological cross sections. These complementary approaches together revealed new physical and biological consequences of laser irradiation: a low-energy interaction regime (pulse energy below ~1 µJ) with very limited cavitation effects and a stronger photo-disruption regime (pulse energy above 1 µJ) with a long cavitation duration from seconds to minutes, resulting in elongated spots. These advances in the understanding of the ultrafast laser's interactions with the lens are of the utmost importance for the preparation of the next-generation treatments that will be applied to the lens.
  • Publisher: Switzerland: MDPI AG
  • Language: English
  • Identifier: ISSN: 2072-666X
    EISSN: 2072-666X
    DOI: 10.3390/mi13122128
    PMID: 36557426
  • Source: PubMed Central
    ROAD: Directory of Open Access Scholarly Resources
    ProQuest Central
    DOAJ Directory of Open Access Journals
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