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Large-Artery Stiffness in Health and Disease: JACC State-of-the-Art Review

Journal of the American College of Cardiology, 2019-09, Vol.74 (9), p.1237-1263 [Peer Reviewed Journal]

Copyright © 2019 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. ;2019. American College of Cardiology Foundation ;ISSN: 0735-1097 ;EISSN: 1558-3597 ;DOI: 10.1016/j.jacc.2019.07.012 ;PMID: 31466622

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Title:
Large-Artery Stiffness in Health and Disease: JACC State-of-the-Art Review
Author: Chirinos, Julio A ; Segers, Patrick ; Hughes, Timothy ; Townsend, Raymond
Subjects: Adult ; Age ; Aged ; Aged, 80 and over ; Aging ; Aorta ; Blood flow ; Blood pressure ; Calcification ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - physiopathology ; Cardiovascular Diseases - therapy ; Child ; Clinical decision making ; Compliance ; Cushioning ; Decision making ; Diabetes ; Disease control ; Female ; Health risks ; Heart ; Hemodynamics ; Humans ; Hypertension ; Male ; Mathematical functions ; Measurement methods ; Microvasculature ; Middle Aged ; Organs ; Risk assessment ; Stiffening ; Stiffness ; Therapeutic applications ; Vascular Stiffness ; Ventricle
Is Part Of: Journal of the American College of Cardiology, 2019-09, Vol.74 (9), p.1237-1263
Description: A healthy aorta exerts a powerful cushioning function, which limits arterial pulsatility and protects the microvasculature from potentially harmful fluctuations in pressure and blood flow. Large-artery (aortic) stiffening, which occurs with aging and various pathologic states, impairs this cushioning function, and has important consequences on cardiovascular health, including isolated systolic hypertension, excessive penetration of pulsatile energy into the microvasculature of target organs that operate at low vascular resistance, and abnormal ventricular-arterial interactions that promote left ventricular remodeling, dysfunction, and failure. Large-artery stiffness independently predicts cardiovascular risk and represents a high-priority therapeutic target to ameliorate the global burden of cardiovascular disease. This paper provides an overview of key physiologic and biophysical principles related to arterial stiffness, the impact of aortic stiffening on target organs, noninvasive methods for the measurement of arterial stiffness, mechanisms leading to aortic stiffening, therapeutic approaches to reduce it, and clinical applications of arterial stiffness measurements.
Publisher: United States: Elsevier Limited
Language: English
Identifier: ISSN: 0735-1097
EISSN: 1558-3597
DOI: 10.1016/j.jacc.2019.07.012
PMID: 31466622
Source: GFMER Free Medical Journals
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Large-Artery Stiffness in Health and Disease: JACC State-of-the-Art Review

Copyright © 2019 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. ;2019. American College of Cardiology Foundation ;ISSN: 0735-1097 ;EISSN: 1558-3597 ;DOI: 10.1016/j.jacc.2019.07.012 ;PMID: 31466622

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