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Serum Levels of Glial Fibrillary Acidic Protein and Neurofilament Light Protein Are Related to the Neurological Impairment and Spinal Edema after Traumatic Spinal Cord Injury

Journal of neurotrauma, 2021-12, Vol.38 (24), p.3431-3439 [Peer Reviewed Journal]

Copyright Mary Ann Liebert, Inc. Dec 2021 ;ISSN: 0897-7151 ;EISSN: 1557-9042 ;DOI: 10.1089/neu.2021.0264 ;PMID: 34541888

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Title:
Serum Levels of Glial Fibrillary Acidic Protein and Neurofilament Light Protein Are Related to the Neurological Impairment and Spinal Edema after Traumatic Spinal Cord Injury
Author: Leister, Iris ; Altendorfer, Barbara ; Maier, Doris ; Mach, Orpheus ; Wutte, Christof ; Grillhösl, Andreas ; Arevalo-Martin, Angel ; Garcia-Ovejero, Daniel ; Aigner, Ludwig ; Grassner, Lukas
Subjects: Adult ; Aged ; Anesthesia ; Biomarkers ; Case-Control Studies ; Decision making ; Edema ; Edema - blood ; Edema - etiology ; Female ; Glial fibrillary acidic protein ; Glial Fibrillary Acidic Protein - blood ; Humans ; Injuries ; Magnetic resonance imaging ; Male ; Middle Aged ; Neurofilament Proteins - blood ; Neurological complications ; Neuronal-glial interactions ; Patients ; Phosphopyruvate hydratase ; Phosphopyruvate Hydratase - blood ; Proteins ; Serum levels ; Serum proteins ; Spinal cord injuries ; Spinal Cord Injuries - blood ; Spinal Cord Injuries - complications ; Spinal cord injury ; Statistical analysis ; Time Factors ; Trauma ; Traumatic brain injury ; Variables
Is Part Of: Journal of neurotrauma, 2021-12, Vol.38 (24), p.3431-3439
Description: Neurological examination in the acute phase after spinal cord injury (SCI) is often impossible and severely confounded by pharmacological sedation or concomitant injuries. Therefore, diagnostic biomarkers that objectively characterize severity or the presence of SCI are urgently needed to facilitate clinical decision-making. This study aimed to determine if serum markers of neural origin are related to: 1) presence and severity of SCI, and 2) magnetic resonance imaging (MRI) parameters in the very acute post-injury phase. We performed a secondary analysis of serological parameters, as well as MRI findings in patients with acute SCI ( = 38). Blood samples were collected between Days 1-4 post-injury. Serum protein levels of glial fibrillary acidic protein (GFAP), neuron-specific enolase (NSE), and neurofilament light protein (NfL) were determined. A group of 41 age- and sex-matched healthy individuals served as control group. In the group of individuals with SCI, pre-operative sagittal and axial T2-weighted and sagittal T1-weighted MRI scans were available for 21 patients. Serum markers of neural origin are different among individuals who sustained traumatic SCI depending on injury severity, and the extent of the lesion according to MRI in the acute injury phase. Unbiased Recursive Partitioning regression with Conditional Inference Trees (URP-CTREE) produced preliminary cut-off values for NfL (75.217 pg/mL) and GFAP (73.121 pg/mL), allowing a differentiation between individuals with SCI and healthy controls within the first 4 days after SCI. Serum proteins NfL and GFAP qualify as diagnostic biomarkers for the presence and severity of SCI in the acute post-injury phase, where the reliability of clinical exams is limited.
Publisher: United States: Mary Ann Liebert, Inc
Language: English
Identifier: ISSN: 0897-7151
EISSN: 1557-9042
DOI: 10.1089/neu.2021.0264
PMID: 34541888
Source: MEDLINE
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Serum Levels of Glial Fibrillary Acidic Protein and Neurofilament Light Protein Are Related to the Neurological Impairment and Spinal Edema after Traumatic Spinal Cord Injury

Copyright Mary Ann Liebert, Inc. Dec 2021 ;ISSN: 0897-7151 ;EISSN: 1557-9042 ;DOI: 10.1089/neu.2021.0264 ;PMID: 34541888

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