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101 PET-CT in patients with suspected paraneoplastic neurological conditions

Journal of neurology, neurosurgery and psychiatry, 2019-12, Vol.90 (12), p.e30-e31 [Peer Reviewed Journal]

Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. ;2019 Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. ;ISSN: 0022-3050 ;EISSN: 1468-330X ;DOI: 10.1136/jnnp-2019-ABN-2.102

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  • Title:
    101 PET-CT in patients with suspected paraneoplastic neurological conditions
  • Author: Cheema, Sanjay ; Young, John ; Pencharz, Deborah
  • Subjects: Patients
  • Is Part Of: Journal of neurology, neurosurgery and psychiatry, 2019-12, Vol.90 (12), p.e30-e31
  • Description: BackgroundPET-CT is often used to investigate for underlying malignancy in patients with suspected paraneoplastic neurological syndromes (PNS). However, evidence supporting its utility is limited, other than in patients with a ‘classical’ PNS, positive antibodies, and after conventional imaging has already been performed and is negative.ResultsWe collected data on 41 consecutive patients with suspected PNS who underwent whole-body PET-CT in our centre. 5/41 (12%) patients were antibody-positive. In 32/41 (78%) CT body imaging had been performed prior to PET-CT.In only one patient did PET-CT uncover a malignancy which was not already known about. In one patient PET-CT led to the diagnosis of neurosarcoidosis, which would not have been identified otherwise. No patients developed a malignancy in the follow up period (range: 10–33 months, median: 22 months) – a negative prediction value (NPV) of 100%.In 29% (12/41) PET-CT showed incidental findings which required further investigation or follow up.ConclusionWe found a low rate of detection of malignancy via PET-CT. This could be explained by low rates of antibody positivity and the small, heterogeneous cohort. The 100% NPV is reassuring. PET-CT identified a non-paraneoplastic condition (sarcoidosis) as a cause of one patient’s symptoms.
  • Publisher: London: BMJ Publishing Group LTD
  • Language: English
  • Identifier: ISSN: 0022-3050
    EISSN: 1468-330X
    DOI: 10.1136/jnnp-2019-ABN-2.102
  • Source: ProQuest One Psychology
    ProQuest Central
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