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Peripartum cardiomyopathy

The Lancet (British edition), 2006-08, Vol.368 (9536), p.687-693 [Peer Reviewed Journal]

2006 Elsevier Ltd ;2006 INIST-CNRS ;Copyright Lancet Ltd. Aug 19-Aug 25, 2006 ;ISSN: 0140-6736 ;EISSN: 1474-547X ;DOI: 10.1016/S0140-6736(06)69253-2 ;PMID: 16920474 ;CODEN: LANCAO

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Title:
Peripartum cardiomyopathy
Author: Sliwa, Karen ; Fett, James ; Elkayam, Uri
Subjects: Adolescent ; Adrenergic beta-Antagonists - therapeutic use ; Adult ; Angiotensin-Converting Enzyme Inhibitors - therapeutic use ; Biological and medical sciences ; Cardiology ; Cardiology. Vascular system ; Cardiomyopathies - drug therapy ; Cardiomyopathies - mortality ; Cardiomyopathies - physiopathology ; Developing countries ; Diuretics - therapeutic use ; Female ; General aspects ; Heart ; Heart attacks ; Heart failure ; Humans ; LDCs ; Medical sciences ; Middle Aged ; Myocarditis. Cardiomyopathies ; Postpartum Period ; Pregnancy ; Pregnancy Complications, Cardiovascular - drug therapy ; Pregnancy Complications, Cardiovascular - mortality ; Pregnancy Complications, Cardiovascular - physiopathology ; Prevalence ; Risk Factors ; Ventricular Function, Left ; Womens health
Is Part Of: The Lancet (British edition), 2006-08, Vol.368 (9536), p.687-693
Description: Peripartum cardiomyopathy (PPCM) is a disorder in which initial left ventricular systolic dysfunction and symptoms of heart failure occur between the late stages of pregnancy and the early postpartum period. It is common in some countries and rare in others. The causes and pathogenesis are poorly understood. Molecular markers of an inflammatory process are found in most patients. Clinical presentation includes usual signs and symptoms of heart failure, and unusual presentations relating to thromboembolism. Clinicians should consider PPCM in any peripartum patient with unexplained disease. Conventional heart failure treatment includes use of diuretics, β blockers, and angiotensin-converting enzyme inhibitors. Effective treatment reduces mortality rates and increases the number of women who fully recover left ventricular systolic function. Outcomes for subsequent pregnancy after PPCM are better in women who have first fully recovered heart function. Areas for future research include immune system dysfunction, the role of viruses, non-conventional treatments such as immunosuppression, immunoadsorption, apheresis, antiviral treatment, suppression of proinflammatory cytokines, and strategies for control and prevention.
Publisher: London: Elsevier Ltd
Language: English
Identifier: ISSN: 0140-6736
EISSN: 1474-547X
DOI: 10.1016/S0140-6736(06)69253-2
PMID: 16920474
CODEN: LANCAO
Source: ProQuest One Psychology
MEDLINE
ProQuest Central

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Peripartum cardiomyopathy

2006 Elsevier Ltd ;2006 INIST-CNRS ;Copyright Lancet Ltd. Aug 19-Aug 25, 2006 ;ISSN: 0140-6736 ;EISSN: 1474-547X ;DOI: 10.1016/S0140-6736(06)69253-2 ;PMID: 16920474 ;CODEN: LANCAO

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