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Immune regulation by glucocorticoids

Nature reviews. Immunology, 2017-04, Vol.17 (4), p.233-247 [Peer Reviewed Journal]

COPYRIGHT 2017 Nature Publishing Group ;COPYRIGHT 2017 Nature Publishing Group ;Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2017. ;ISSN: 1474-1733 ;EISSN: 1474-1741 ;DOI: 10.1038/nri.2017.1 ;PMID: 28192415

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Title:
Immune regulation by glucocorticoids
Author: Cain, Derek W ; Cidlowski, John A
Subjects: Adaptive immunity ; Animals ; Apoptosis ; Cell activation ; Circadian rhythms ; Corticosteroids ; Cytokine receptors ; Cytokines ; Deoxyribonucleic acid ; DNA ; Genetic aspects ; Glucocorticoid receptors ; Glucocorticoids ; Glucocorticoids - immunology ; Glucocorticoids - pharmacology ; Health aspects ; Humans ; Hypothalamus ; Immune response ; Immune response regulation ; Immune System - drug effects ; Immune System - physiology ; Immunoregulation ; Immunosuppression ; Immunosuppressive Agents - immunology ; Immunosuppressive Agents - pharmacology ; Inflammation ; Inflammation - drug therapy ; Innate immunity ; Ligands ; Lymphocytes B ; Lymphocytes T ; Macrophages ; Medical research ; Medicine, Experimental ; Pattern recognition ; Pituitary ; Protein interaction ; Regulation ; Regulatory sequences ; Signal transduction ; Transcription factors ; Ultradian rhythms
Is Part Of: Nature reviews. Immunology, 2017-04, Vol.17 (4), p.233-247
Description: Endogenous glucocorticoids are crucial to various physiological processes, including metabolism, development and inflammation. Since 1948, synthetic glucocorticoids have been used to treat various immune-related disorders. The mechanisms that underlie the immunosuppressive properties of these hormones have been intensely scrutinized, and it is widely appreciated that glucocorticoids have pleiotropic effects on the immune system. However, a clear picture of the cellular and molecular basis of glucocorticoid action has remained elusive. In this Review, we distil several decades of intense (and often conflicting) research that defines the interface between the endocrine stress response and the immune system.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1474-1733
EISSN: 1474-1741
DOI: 10.1038/nri.2017.1
PMID: 28192415
Source: MEDLINE
ProQuest Central

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Immune regulation by glucocorticoids

COPYRIGHT 2017 Nature Publishing Group ;COPYRIGHT 2017 Nature Publishing Group ;Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2017. ;ISSN: 1474-1733 ;EISSN: 1474-1741 ;DOI: 10.1038/nri.2017.1 ;PMID: 28192415

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