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Bile acids in glucose metabolism and insulin signalling - mechanisms and research needs

Nature reviews. Endocrinology, 2019-12, Vol.15 (12), p.701-712 [Peer Reviewed Journal]

COPYRIGHT 2019 Nature Publishing Group ;Copyright Nature Publishing Group Dec 2019 ;ISSN: 1759-5029 ;EISSN: 1759-5037 ;DOI: 10.1038/s41574-019-0266-7 ;PMID: 31616073

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Title:
Bile acids in glucose metabolism and insulin signalling - mechanisms and research needs
Author: Ahmad, Tiara R ; Haeusler, Rebecca A
Subjects: Acids ; Allosteric properties ; Amino acids ; Analysis ; Animal models ; Animals ; Bile ; Bile acids ; Bile Acids and Salts - metabolism ; Biomedical Research - trends ; Cell culture ; Cholesterol ; Dextrose ; Glucose ; Glucose - metabolism ; Glycemic Index - physiology ; Health aspects ; Homeostasis ; Humans ; Insulin ; Insulin - metabolism ; Medical research ; Medicine, Experimental ; Metabolic Diseases - metabolism ; Metabolic Diseases - therapy ; Metabolic regulation ; N-acyl phosphatidylethanolamine ; Organoids ; Phosphatidylethanolamine ; Phospholipase ; Phospholipase D ; Phospholipids ; Physiological aspects ; Physiology ; Secretion ; Signal transduction
Is Part Of: Nature reviews. Endocrinology, 2019-12, Vol.15 (12), p.701-712
Description: Of all the novel glucoregulatory molecules discovered in the past 20 years, bile acids (BAs) are notable for the fact that they were hiding in plain sight. BAs were well known for their requirement in dietary lipid absorption and biliary cholesterol secretion, due to their micelle-forming properties. However, it was not until 1999 that BAs were discovered to be endogenous ligands for the nuclear receptor FXR. Since that time, BAs have been shown to act through multiple receptors (PXR, VDR, TGR5 and S1PR2), as well as to have receptor-independent mechanisms (membrane dynamics, allosteric modulation of N-acyl phosphatidylethanolamine phospholipase D). We now also have an appreciation of the range of physiological, pathophysiological and therapeutic conditions in which endogenous BAs are altered, raising the possibility that BAs contribute to the effects of these conditions on glycaemia. In this Review, we highlight the mechanisms by which BAs regulate glucose homeostasis and the settings in which endogenous BAs are altered, and provide suggestions for future research.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1759-5029
EISSN: 1759-5037
DOI: 10.1038/s41574-019-0266-7
PMID: 31616073
Source: MEDLINE
ProQuest Central

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Bile acids in glucose metabolism and insulin signalling - mechanisms and research needs

COPYRIGHT 2019 Nature Publishing Group ;Copyright Nature Publishing Group Dec 2019 ;ISSN: 1759-5029 ;EISSN: 1759-5037 ;DOI: 10.1038/s41574-019-0266-7 ;PMID: 31616073

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