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DIAGNOSIS OF ENDOCRINE DISEASE: Expanding the cause of hypopituitarism

European journal of endocrinology, 2017-06, Vol.176 (6), p.R269-R282 [Peer Reviewed Journal]

2017 European Society of Endocrinology ;2017 European Society of Endocrinology. ;Copyright BioScientifica Ltd. Jun 2017 ;ISSN: 0804-4643 ;EISSN: 1479-683X ;DOI: 10.1530/EJE-16-1065 ;PMID: 28258131

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Title:
DIAGNOSIS OF ENDOCRINE DISEASE: Expanding the cause of hypopituitarism
Author: Pekic, Sandra ; Popovic, Vera
Subjects: Adenoma ; Adenoma - complications ; Adenoma - diagnosis ; Brain Abscess - complications ; Brain Abscess - diagnosis ; Brain Injuries, Traumatic - complications ; Central Nervous System Infections - complications ; Central Nervous System Infections - diagnosis ; Cranial Irradiation - adverse effects ; Diagnosis ; Diagnosis, Differential ; Early Diagnosis ; Early Medical Intervention ; Erdheim-Chester Disease - complications ; Erdheim-Chester Disease - diagnosis ; Genetic disorders ; Glomus Tumor - complications ; Glomus Tumor - diagnosis ; Granulomatosis with Polyangiitis - complications ; Granulomatosis with Polyangiitis - diagnosis ; Hemochromatosis ; Hemochromatosis - complications ; Hemochromatosis - diagnosis ; Hemosiderosis - complications ; Hemosiderosis - diagnosis ; Histiocytosis, Langerhans-Cell - complications ; Histiocytosis, Langerhans-Cell - diagnosis ; Hormone Replacement Therapy ; Humans ; Hypophysitis - complications ; Hypophysitis - diagnosis ; Hypopituitarism ; Hypopituitarism - diagnosis ; Hypopituitarism - drug therapy ; Hypopituitarism - etiology ; Hypothalamus ; Infectious diseases ; Inflammatory diseases ; Intracranial Aneurysm - complications ; Intracranial Aneurysm - diagnosis ; Life span ; Lymphoma - complications ; Lymphoma - diagnosis ; Neurosyphilis - complications ; Neurosyphilis - diagnosis ; Pituitary ; Pituitary Apoplexy - complications ; Pituitary Apoplexy - diagnosis ; Pituitary hormones ; Pituitary Neoplasms - complications ; Pituitary Neoplasms - diagnosis ; Pituitary Neoplasms - secondary ; Plasmacytoma - complications ; Plasmacytoma - diagnosis ; Puerperal Disorders - diagnosis ; Quality of life ; Review ; Sarcoidosis ; Sarcoidosis - complications ; Sarcoidosis - diagnosis ; Sella Turcica ; Subarachnoid Hemorrhage - complications ; Subarachnoid Hemorrhage - diagnosis ; Traumatic brain injury ; Tuberculosis, Central Nervous System - complications ; Tuberculosis, Central Nervous System - diagnosis
Is Part Of: European journal of endocrinology, 2017-06, Vol.176 (6), p.R269-R282
Description: Hypopituitarism is defined as one or more pituitary hormone deficits due to a lesion in the hypothalamic–pituitary region. By far, the most common cause of hypopituitarism associated with a sellar mass is a pituitary adenoma. A high index of suspicion is required for diagnosing hypopituitarism in several other conditions such as other massess in the sellar and parasellar region, brain damage caused by radiation and by traumatic brain injury, vascular lesions, infiltrative/immunological/inflammatory diseases (lymphocytic hypophysitis, sarcoidosis and hemochromatosis), infectious diseases and genetic disorders. Hypopituitarism may be permanent and progressive with sequential pattern of hormone deficiencies (radiation-induced hypopituitarism) or transient after traumatic brain injury with possible recovery occurring years from the initial event. In recent years, there is increased reporting of less common and less reported causes of hypopituitarism with its delayed diagnosis. The aim of this review is to summarize the published data and to allow earlier identification of populations at risk of hypopituitarism as optimal hormonal replacement may significantly improve their quality of life and life expectancy.
Publisher: England: Bioscientifica Ltd
Language: English
Identifier: ISSN: 0804-4643
EISSN: 1479-683X
DOI: 10.1530/EJE-16-1065
PMID: 28258131
Source: GFMER Free Medical Journals
MEDLINE

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DIAGNOSIS OF ENDOCRINE DISEASE: Expanding the cause of hypopituitarism

2017 European Society of Endocrinology ;2017 European Society of Endocrinology. ;Copyright BioScientifica Ltd. Jun 2017 ;ISSN: 0804-4643 ;EISSN: 1479-683X ;DOI: 10.1530/EJE-16-1065 ;PMID: 28258131

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