skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Prolidase activity in women with polycystic ovarian syndrome undergoing assisted conception

Journal of obstetrics and gynaecology, 2024-12, Vol.44 (1) [Peer Reviewed Journal]

ISSN: 0144-3615 ;EISSN: 1364-6893 ;DOI: 10.1080/01443615.2024.2346228

Full text available

Citations Cited by
  • Title:
    Prolidase activity in women with polycystic ovarian syndrome undergoing assisted conception
  • Author: Kadriye Erdoğan ; Emine Utlu Özen ; İnci Kahyaoğlu ; Salim Neselioglu ; Özcan Erel ; Serra Akar ; Özhan Özdemir ; Cihangir Mutlu Ercan ; Yaprak Engin Üstün
  • Subjects: Assisted conception ; polycystic ovary syndrome ; prolidase activity
  • Is Part Of: Journal of obstetrics and gynaecology, 2024-12, Vol.44 (1)
  • Description: AbstractBackground: Prolidase is a manganese (Mn)-dependent cytosolic exopeptidase that degrades imidodipeptides with C-terminal proline or hydroxyproline. Prolidase recycling from imidodipeptides plays a critical role in collagen resynthesis and extracellular matrix (ECM) remodelling. Following an increase in gonadotropins, ovarian and follicular collagen undergo substantial degradation. Abnormal ovarian ECM composition is associated with polycystic ovary syndrome (PCOS). This study aimed to examine prolidase activity in the serum and follicular fluid (FF) of women undergoing in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI) treatment, comparing those with PCOS to those with normal ovarian function.Methods: This prospective study enrolled 50 participants, of whom 44 were included. PCOS diagnosis followed the Rotterdam consensus criteria, with 20 patients constituting the study group. The control group comprised 24 individuals with mild-to-moderate male infertility. Prolidase enzyme activity in serum and FF was measured using the Chinard reagent via spectrophotometric analysis and compared between the groups.Results: Serum and FF prolidase levels were significantly lower in patients with PCOS (p < 0.05). A direct correlation was observed between serum and FF prolidase levels (p < 0.05). Although blastocyst quality scoring (BQS) significantly decreased in PCOS patients, no statistical difference was observed in the clinical pregnancy rate between the groups (p < 0.05) (p > 0.05). A negative correlation existed between serum prolidase levels and total antral follicle (AF) count (p < 0.05). Conversely, both serum and FF prolidase levels positively correlated with BQS (r = 0.574)(p < 0.05) (r = 0.650)(p < 0.05).Conclusions: Patients with PCOS showed lower serum and FF prolidase levels, indicating abnormal degradation of ovarian and follicular collagen, potentially causing anovulation.
  • Publisher: Taylor & Francis Group
  • Language: English
  • Identifier: ISSN: 0144-3615
    EISSN: 1364-6893
    DOI: 10.1080/01443615.2024.2346228
  • Source: DOAJ Directory of Open Access Journals
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait