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C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

Immunity (Cambridge, Mass.), 2015-04, Vol.42 (4), p.665-678 [Peer Reviewed Journal]

2015 Elsevier Inc. ;Copyright © 2015 Elsevier Inc. All rights reserved. ;Copyright Elsevier Limited Apr 21, 2015 ;ISSN: 1074-7613 ;EISSN: 1097-4180 ;DOI: 10.1016/j.immuni.2015.03.011 ;PMID: 25902481

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Title:
C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages
Author: Hoeffel, Guillaume ; Chen, Jinmiao ; Lavin, Yonit ; Low, Donovan ; Almeida, Francisca F. ; See, Peter ; Beaudin, Anna E. ; Lum, Josephine ; Low, Ivy ; Forsberg, E. Camilla ; Poidinger, Michael ; Zolezzi, Francesca ; Larbi, Anis ; Ng, Lai Guan ; Chan, Jerry K.Y. ; Greter, Melanie ; Becher, Burkhard ; Samokhvalov, Igor M. ; Merad, Miriam ; Ginhoux, Florent
Subjects: Aging - immunology ; Animals ; Biomarkers - metabolism ; Cell Differentiation ; Cell Lineage - immunology ; Cell Tracking ; Cloning ; Embryo, Mammalian ; Embryos ; Female ; Fetus ; Flow cytometry ; Gene expression ; Hematopoietic Stem Cells - cytology ; Hematopoietic Stem Cells - immunology ; Homeostasis ; Kidney - cytology ; Kidney - immunology ; Liver - cytology ; Liver - immunology ; Lung - cytology ; Lung - immunology ; Macrophages - cytology ; Macrophages - immunology ; Mice ; Microglia - cytology ; Microglia - immunology ; Monocytes - cytology ; Monocytes - immunology ; Myeloid Progenitor Cells - cytology ; Myeloid Progenitor Cells - immunology ; Pregnancy ; Primary Cell Culture ; Proto-Oncogene Proteins c-myb - immunology ; Proto-Oncogene Proteins c-myb - metabolism ; Rodents ; Skin ; Skin - cytology ; Skin - immunology ; Software ; Stem cells ; Yolk Sac - cytology ; Yolk Sac - immunology
Is Part Of: Immunity (Cambridge, Mass.), 2015-04, Vol.42 (4), p.665-678
Description: Although classified as hematopoietic cells, tissue-resident macrophages (MFs) arise from embryonic precursors that seed the tissues prior to birth to generate a self-renewing population, which is maintained independently of adult hematopoiesis. Here we reveal the identity of these embryonic precursors using an in utero MF-depletion strategy and fate-mapping of yolk sac (YS) and fetal liver (FL) hematopoiesis. We show that YS MFs are the main precursors of microglia, while most other MFs derive from fetal monocytes (MOs). Both YS MFs and fetal MOs arise from erythro-myeloid progenitors (EMPs) generated in the YS. In the YS, EMPs gave rise to MFs without monocytic intermediates, while EMP seeding the FL upon the establishment of blood circulation acquired c-Myb expression and gave rise to fetal MOs that then seeded embryonic tissues and differentiated into MFs. Thus, adult tissue-resident MFs established from hematopoietic stem cell-independent embryonic precursors arise from two distinct developmental programs. [Display omitted] •Fetal tissue macrophages arise from two distinct developmental programs•Early EMPs give rise to yolk sac macrophages without monocytic intermediates•Late c-Myb+ EMPs seed the fetal liver and give rise to fetal monocytes•Fetal monocytes differentiate into macrophages able to self-renew into adulthood The identity of the embryonic precursors that give rise to adult tissue-resident macrophages is controversial. Here, Ginhoux and colleagues show that yolk sac macrophages are the main precursors of microglia, whereas most other macrophages derive from fetal monocytes that arise from late c-myb+ erythro-myeloid progenitors generated in the yolk sac.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 1074-7613
EISSN: 1097-4180
DOI: 10.1016/j.immuni.2015.03.011
PMID: 25902481
Source: Cell Press Free Archives
MEDLINE

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C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

2015 Elsevier Inc. ;Copyright © 2015 Elsevier Inc. All rights reserved. ;Copyright Elsevier Limited Apr 21, 2015 ;ISSN: 1074-7613 ;EISSN: 1097-4180 ;DOI: 10.1016/j.immuni.2015.03.011 ;PMID: 25902481

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