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SREBPs: physiology and pathophysiology of the SREBP family

The FEBS journal, 2009-02, Vol.276 (3), p.616-621 [Peer Reviewed Journal]

2008 The Author Journal compilation © 2008 FEBS ;Journal compilation © 2009 Federation of European Biochemical Societies ;ISSN: 1742-464X ;EISSN: 1742-4658 ;DOI: 10.1111/j.1742-4658.2008.06806.x ;PMID: 19143830

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Title:
SREBPs: physiology and pathophysiology of the SREBP family
Author: Shimano, Hitoshi
Subjects: Animals ; Biochemistry ; Cardiology ; cholesterol ; diabetes ; Disease ; dyslipidemia ; fatty acids ; fatty liver ; Humans ; hyperlipidemia ; Insulin Resistance ; Lipid Metabolism ; Lipids ; lipotoxicity ; metabolic syndrome ; Molecular biology ; Obesity ; Organ Specificity ; Proteins ; SREBP ; Sterol Regulatory Element Binding Proteins - classification ; Sterol Regulatory Element Binding Proteins - genetics ; Sterol Regulatory Element Binding Proteins - metabolism ; Sterols - metabolism ; trigylcerides
Is Part Of: The FEBS journal, 2009-02, Vol.276 (3), p.616-621
Description: Sterol regulatory element-binding proteins (SREBPs) have been established as physiological regulators of lipid synthesis. The molecular mechanisms by which cellular sterol balance and nutritional states regulate SREBP activities are the current research focus of this field. Meanwhile, it has been shown that overnutrition or disturbed energy balance causes accumulation of tissue lipids, leading to metabolic disorders, often referred to as 'lipotoxicity'. In this overview, I discuss the pathological aspects of SREBPs, which contribute to lipotoxicity in a wide variety of organs, including hepatic insulin resistance in hepatosteatosis, impaired insulin secretion in pancreatic β-cells, diabetic nephropathy, cardiac arrythmiasis, and obesity.
Publisher: Oxford, UK: Oxford, UK : Blackwell Publishing Ltd
Language: English
Identifier: ISSN: 1742-464X
EISSN: 1742-4658
DOI: 10.1111/j.1742-4658.2008.06806.x
PMID: 19143830
Source: IngentaConnect
Geneva Foundation Free Medical Journals at publisher websites
MEDLINE

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SREBPs: physiology and pathophysiology of the SREBP family

2008 The Author Journal compilation © 2008 FEBS ;Journal compilation © 2009 Federation of European Biochemical Societies ;ISSN: 1742-464X ;EISSN: 1742-4658 ;DOI: 10.1111/j.1742-4658.2008.06806.x ;PMID: 19143830

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