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CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract

World journal of gastroenterology : WJG, 2009-06, Vol.15 (23), p.2855-2861

Copyright © Wanfang Data Co. Ltd. All Rights Reserved. ;2009 The WJG Press and Baishideng. All rights reserved. 2009 ;ISSN: 1007-9327 ;EISSN: 2219-2840 ;DOI: 10.3748/wjg.15.2855 ;PMID: 19533806

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Title:
CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract
Author: Beswick, Ellen J ; Reyes, Victor E
Subjects: Antigen Presentation - immunology ; Antigens, Differentiation, B-Lymphocyte - immunology ; Gastrointestinal Neoplasms - immunology ; Helicobacter Infections - immunology ; Helicobacter pylori - immunology ; Histocompatibility Antigens Class II - immunology ; Humans ; Inflammation - immunology ; Interleukin-8 - immunology ; Macrophage Migration-Inhibitory Factors - immunology ; Protein Isoforms - immunology ; Review ; Signal Transduction - immunology ; 幽门螺旋杆菌 ; 幽门螺杆菌 ; 抑制因子 ; 抗原提呈 ; 炎性细胞因子 ; 胃肠道
Is Part Of: World journal of gastroenterology : WJG, 2009-06, Vol.15 (23), p.2855-2861
Description: CD74 is a protein whose initial role in antigen presentation was recognized two decades ago. Recent studies have revealed that it has additional functions as a receptor for macrophage migration inhibitory factor and as a receptor for an important human pathogen, Helicobacter pylori （H pylon）. The role of CD74 as a receptor is important because after binding of migration inhibitory factor or H pylori, NF-κB and Erkl/2 activation occurs, along with the induction of proinflammatory cytokine secretion. This review provides an up-to-date account of the functions of CD74 and how it might be involved in inflammation and cancer within the gastrointestinal tract.
Publisher: United States: Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555, United States%Department of Pediatrics and Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, United States
Language: English
Identifier: ISSN: 1007-9327
EISSN: 2219-2840
DOI: 10.3748/wjg.15.2855
PMID: 19533806
Source: Open Access: PubMed Central
GFMER Free Medical Journals
MEDLINE
Alma/SFX Local Collection

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CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract

Copyright © Wanfang Data Co. Ltd. All Rights Reserved. ;2009 The WJG Press and Baishideng. All rights reserved. 2009 ;ISSN: 1007-9327 ;EISSN: 2219-2840 ;DOI: 10.3748/wjg.15.2855 ;PMID: 19533806

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