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Targeting adipose tissue in the treatment of obesity-associated diabetes
Nature reviews. Drug discovery, 2016-09, Vol.15 (9), p.639-660
[Peer Reviewed Journal]
Copyright Nature Publishing Group Sep 2016 ;ISSN: 1474-1776 ;EISSN: 1474-1784 ;DOI: 10.1038/nrd.2016.75 ;PMID: 27256476
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Title:
Targeting adipose tissue in the treatment of obesity-associated diabetes
Author:
Kusminski, Christine M
;
Bickel, Perry E
;
Scherer, Philipp E
Subjects:
Adipose Tissue - drug effects
;
Adipose Tissue - pathology
;
Adipose Tissue - physiopathology
;
Animals
;
Diabetes Mellitus, Type 2 - complications
;
Diabetes Mellitus, Type 2 - drug therapy
;
Homeostasis - drug effects
;
Humans
;
Insulin Resistance
;
Obesity - drug therapy
;
Obesity - pathology
;
Obesity - physiopathology
Is Part Of:
Nature reviews. Drug discovery, 2016-09, Vol.15 (9), p.639-660
Description:
Adipose tissue regulates numerous physiological processes, and its dysfunction in obese humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 diabetes mellitus (T2DM). Although several US-approved treatments for obesity and T2DM exist, these are limited by adverse effects and a lack of effective long-term glucose control. In this Review, we provide an overview of the role of adipose tissue in metabolic homeostasis and assess emerging novel therapeutic strategies targeting adipose tissue, including adipokine-based strategies, promotion of white adipose tissue beiging as well as reduction of inflammation and fibrosis.
Publisher:
England: Nature Publishing Group
Language:
English
Identifier:
ISSN: 1474-1776
EISSN: 1474-1784
DOI: 10.1038/nrd.2016.75
PMID: 27256476
Source:
MEDLINE
ProQuest Central
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