Language:

Effect of Plasma Uric Acid on Antioxidant Capacity, Oxidative Stress, and Insulin Sensitivity in Obese Subjects

Diabetes (New York, N.Y.), 2014-03, Vol.63 (3), p.976-981 [Peer Reviewed Journal]

2015 INIST-CNRS ;COPYRIGHT 2014 American Diabetes Association ;COPYRIGHT 2014 American Diabetes Association ;Copyright American Diabetes Association Mar 2014 ;2014 by the American Diabetes Association. 2014 ;ISSN: 0012-1797 ;EISSN: 1939-327X ;DOI: 10.2337/db13-1396 ;PMID: 24353177 ;CODEN: DIAEAZ

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Effect of Plasma Uric Acid on Antioxidant Capacity, Oxidative Stress, and Insulin Sensitivity in Obese Subjects
Author: FABBRINI, Elisa ; SERAFINI, Mauro ; BARIC, Irena Colic ; HAZEN, Stanley L ; KLEIN, Samuel
Subjects: Antioxidants ; Antioxidants - metabolism ; Biochemistry ; Biological and medical sciences ; Biomarkers ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Health aspects ; Humans ; Insulin Resistance ; Male ; Medical research ; Medical sciences ; Medicine, Experimental ; Metabolic diseases ; Middle Aged ; Obesity ; Obesity - metabolism ; Obesity Studies ; Overweight persons ; Oxidative Stress ; Pathogenesis ; Physiological aspects ; Uric acid ; Uric Acid - blood
Is Part Of: Diabetes (New York, N.Y.), 2014-03, Vol.63 (3), p.976-981
Description: Oxidative stress is purported to be involved in the pathogenesis of obesity-associated insulin resistance. We evaluated whether alterations in levels of circulating uric acid (UA), a systemic antioxidant, affects the following: 1) systemic (plasma and saliva) nonenzymatic antioxidant capacity (NEAC); 2) markers of systemic (urinary 8-iso-prostaglandin-F2α) and muscle (carbonylated protein content) oxidative stress; and 3) whole-body insulin sensitivity (percentage increase in glucose uptake during a hyperinsulinemic-euglycemic clamp procedure). Thirty-one obese subjects (BMI 37.1 ± 0.7 kg/m(2)) with either high serum UA (HUA; 7.1 ± 0.4 mg/dL; n = 15) or normal serum UA (NUA; 4.5 ± 0.2 mg/dL; n = 16) levels were studied; 13 subjects with HUA levels were studied again after reduction of serum UA levels to 0 by infusing a recombinant urate oxidase. HUA subjects had 20-90% greater NEAC, but lower insulin sensitivity (40%) and levels of markers of oxidative stress (30%) than subjects in the NUA group (all P < 0.05). Acute UA reduction caused a 45-95% decrease in NEAC and a 25-40% increase in levels of systemic and muscle markers of oxidative stress (all P < 0.05), but did not affect insulin sensitivity (from 168 ± 25% to 156 ± 17%, P = NS). These results demonstrate that circulating UA is a major antioxidant and might help protect against free-radical oxidative damage. However, oxidative stress is not a major determinant of insulin action in vivo.
Publisher: Alexandria, VA: American Diabetes Association
Language: English
Identifier: ISSN: 0012-1797
EISSN: 1939-327X
DOI: 10.2337/db13-1396
PMID: 24353177
CODEN: DIAEAZ
Source: MEDLINE
PubMed Central
Alma/SFX Local Collection

Back to results list

Previous Result 89 Next Go to Next page


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Effect of Plasma Uric Acid on Antioxidant Capacity, Oxidative Stress, and Insulin Sensitivity in Obese Subjects

2015 INIST-CNRS ;COPYRIGHT 2014 American Diabetes Association ;COPYRIGHT 2014 American Diabetes Association ;Copyright American Diabetes Association Mar 2014 ;2014 by the American Diabetes Association. 2014 ;ISSN: 0012-1797 ;EISSN: 1939-327X ;DOI: 10.2337/db13-1396 ;PMID: 24353177 ;CODEN: DIAEAZ

Searching Remote Databases, Please Wait