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Health and disease markers correlate with gut microbiome composition across thousands of people

Nature communications, 2020-10, Vol.11 (1), p.5206-5206, Article 5206 [Peer Reviewed Journal]

The Author(s) 2020 ;ISSN: 2041-1723 ;EISSN: 2041-1723 ;DOI: 10.1038/s41467-020-18871-1 ;PMID: 33060586

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  • Title:
    Health and disease markers correlate with gut microbiome composition across thousands of people
  • Author: Manor, Ohad ; Dai, Chengzhen L. ; Kornilov, Sergey A. ; Smith, Brett ; Price, Nathan D. ; Lovejoy, Jennifer C. ; Gibbons, Sean M. ; Magis, Andrew T.
  • Is Part Of: Nature communications, 2020-10, Vol.11 (1), p.5206-5206, Article 5206
  • Description: Abstract Variation in the human gut microbiome can reflect host lifestyle and behaviors and influence disease biomarker levels in the blood. Understanding the relationships between gut microbes and host phenotypes are critical for understanding wellness and disease. Here, we examine associations between the gut microbiota and ~150 host phenotypic features across ~3,400 individuals. We identify major axes of taxonomic variance in the gut and a putative diversity maximum along the Firmicutes-to-Bacteroidetes axis. Our analyses reveal both known and unknown associations between microbiome composition and host clinical markers and lifestyle factors, including host-microbe associations that are composition-specific. These results suggest potential opportunities for targeted interventions that alter the composition of the microbiome to improve host health. By uncovering the interrelationships between host diet and lifestyle factors, clinical blood markers, and the human gut microbiome at the population-scale, our results serve as a roadmap for future studies on host-microbe interactions and interventions.
  • Publisher: London: Nature Publishing Group UK
  • Language: English
  • Identifier: ISSN: 2041-1723
    EISSN: 2041-1723
    DOI: 10.1038/s41467-020-18871-1
    PMID: 33060586
  • Source: Open Access: DOAJ Directory of Open Access Journals
    Open Access: PubMed Central
    AUTh Library subscriptions: ProQuest Central
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