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The prognostic significance of tumour―stroma ratio in oestrogen receptor-positive breast cancer

British journal of cancer, 2014-04, Vol.110 (7), p.1744-1747 [Peer Reviewed Journal]

2015 INIST-CNRS ;Copyright Nature Publishing Group Apr 1, 2014 ;Copyright © 2014 Cancer Research UK 2014 Cancer Research UK ;ISSN: 0007-0920 ;EISSN: 1532-1827 ;DOI: 10.1038/bjc.2014.69 ;PMID: 24548861 ;CODEN: BJCAAI

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Title:
The prognostic significance of tumour―stroma ratio in oestrogen receptor-positive breast cancer
Author: DOWNEY, C. L ; SIMPKINS, S. A ; HANBY, A. M ; SPEIRS, V ; WHITE, J ; HOLLIDAY, D. L ; JONES, J. L ; JORDAN, L. B ; KULKA, J ; POLLOCK, S ; RAJAN, S. S ; THYGESEN, H. H
Subjects: Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Breast Neoplasms - diagnosis ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Breast Neoplasms, Male - diagnosis ; Breast Neoplasms, Male - metabolism ; Breast Neoplasms, Male - mortality ; Breast Neoplasms, Male - pathology ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Male ; Mammary gland diseases ; Medical sciences ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Receptors, Estrogen - metabolism ; Short Communication ; Stromal Cells - pathology ; Survival Analysis ; Tumor Burden ; Tumors
Is Part Of: British journal of cancer, 2014-04, Vol.110 (7), p.1744-1747
Description: A high percentage of stroma predicts poor survival in triple-negative breast cancers but is diminished in studies of unselected cases. We determined the prognostic significance of tumour-stroma ratio (TSR) in oestrogen receptor (ER)-positive male and female breast carcinomas. TSR was measured in haematoxylin and eosin-stained tissue sections (118 female and 62 male). Relationship of TSR (cutoff 49%) to overall survival (OS) and relapse-free survival (RFS) was analysed. Tumours with ≥49% stroma were associated with better survival in female (OS P=0.008, HR=0.2-0.7; RFS P=0.006, HR=0.1-0.6) and male breast cancer (OS P=0.005, HR=0.05-0.6; RFS P=0.01, HR=0.87-5.6), confirmed in multivariate analysis. High stromal content was related to better survival in ER-positive breast cancers across both genders, contrasting data in triple-negative breast cancer and highlighting the importance of considering ER status when interpreting the prognostic value of TSR.
Publisher: Basingstoke: Nature Publishing Group
Language: English
Identifier: ISSN: 0007-0920
EISSN: 1532-1827
DOI: 10.1038/bjc.2014.69
PMID: 24548861
CODEN: BJCAAI
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
ProQuest Central

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The prognostic significance of tumour―stroma ratio in oestrogen receptor-positive breast cancer

2015 INIST-CNRS ;Copyright Nature Publishing Group Apr 1, 2014 ;Copyright © 2014 Cancer Research UK 2014 Cancer Research UK ;ISSN: 0007-0920 ;EISSN: 1532-1827 ;DOI: 10.1038/bjc.2014.69 ;PMID: 24548861 ;CODEN: BJCAAI

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