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Drug-Induced Macular Edema

Drugs (New York, N.Y.), 2013-06, Vol.73 (8), p.789-802 [Peer Reviewed Journal]

Springer International Publishing Switzerland 2013 ;2014 INIST-CNRS ;Copyright Wolters Kluwer Health Adis International Jun 2013 ;ISSN: 0012-6667 ;EISSN: 1179-1950 ;DOI: 10.1007/s40265-013-0055-x ;PMID: 23640687 ;CODEN: DRUGAY

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Title:
Drug-Induced Macular Edema
Author: Makri, Olga E. ; Georgalas, Ilias ; Georgakopoulos, Constantine D.
Subjects: Adrenergic beta-Antagonists - adverse effects ; Antidiabetics ; Antineoplastic Agents - adverse effects ; Biological and medical sciences ; Cancer ; Diabetes ; Disease ; Drugs ; Edema ; Fingolimod Hydrochloride ; Humans ; Hypolipidemic Agents - adverse effects ; Immunosuppressive Agents - adverse effects ; Insulin ; Interferons - adverse effects ; Internal Medicine ; Macular Edema - chemically induced ; Macular Edema - diagnosis ; Medical sciences ; Medicine ; Medicine & Public Health ; Multiple sclerosis ; Niacin - adverse effects ; Ophthalmic Solutions - adverse effects ; Ophthalmology ; Permeability ; Pharmacology/Toxicology ; Pharmacotherapy ; Propylene Glycols - adverse effects ; Quality of life ; Retina ; Retinopathies ; Review Article ; Sphingosine - adverse effects ; Sphingosine - analogs & derivatives ; Tamoxifen - adverse effects ; Taxoids - adverse effects ; Thiazolidinediones - adverse effects ; Timolol - adverse effects
Is Part Of: Drugs (New York, N.Y.), 2013-06, Vol.73 (8), p.789-802
Description: Macular edema constitutes a serious pathologic entity of ophthalmology resulting in vision loss with a remarkable impact on the quality of life of patients. It is the final common pathway of various systemic diseases and underlying intraocular conditions, with diabetes mellitus being the most frequent cause. Other causes include venous occlusive disease, intraocular surgery, and inflammatory conditions of the posterior segment of the eye. Macular edema is a recognized side effect of various systemic and local medications and requires special consideration among ophthalmologists and other clinicians. Recently, antidiabetic thiazolidinediones have been implicated in the development of macular edema, and a review of the English literature revealed that other systemically administered drugs like fingolimod, recently approved for relapsing forms of multiple sclerosis, the anticancer agents tamoxifen and the taxanes, as well as niacin and interferons have been reported to cause macular edema. Ophthalmologic pharmaceutical agents, like prostaglandin analogs, epinephrine, timolol, and ophthalmic preparation preservatives have also been reported to cause macular edema as an adverse event. The purpose of this article is to provide a short, balanced overview of the available evidence in this regard. The available data and the possible pathophysiologic mechanisms leading to the development of macular edema are discussed. Possible therapeutic strategies for drug-induced macular edema are also proposed.
Publisher: Cham: Springer International Publishing AG
Language: English
Identifier: ISSN: 0012-6667
EISSN: 1179-1950
DOI: 10.1007/s40265-013-0055-x
PMID: 23640687
CODEN: DRUGAY
Source: MEDLINE
ProQuest Central

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Drug-Induced Macular Edema

Springer International Publishing Switzerland 2013 ;2014 INIST-CNRS ;Copyright Wolters Kluwer Health Adis International Jun 2013 ;ISSN: 0012-6667 ;EISSN: 1179-1950 ;DOI: 10.1007/s40265-013-0055-x ;PMID: 23640687 ;CODEN: DRUGAY

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