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Galectin-3, a Marker of Cardiac Fibrosis, Predicts Incident Heart Failure in the Community

Journal of the American College of Cardiology, 2012-10, Vol.60 (14), p.1249-1256 [Peer Reviewed Journal]

American College of Cardiology Foundation ;2012 American College of Cardiology Foundation ;2014 INIST-CNRS ;Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. ;Copyright Elsevier Limited Oct 2, 2012 ;2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. 2012 ;ISSN: 0735-1097 ;EISSN: 1558-3597 ;DOI: 10.1016/j.jacc.2012.04.053 ;PMID: 22939561 ;CODEN: JACCDI

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Title:
Galectin-3, a Marker of Cardiac Fibrosis, Predicts Incident Heart Failure in the Community
Author: Ho, Jennifer E., MD ; Liu, Chunyu, PhD ; Lyass, Asya, PhD ; Courchesne, Paul, MBA ; Pencina, Michael J., PhD ; Vasan, Ramachandran S., MD ; Larson, Martin G., ScD ; Levy, Daniel, MD
Subjects: Aged ; Biological and medical sciences ; biomarker ; Biomarkers - blood ; Cardiology. Vascular system ; Cardiovascular ; Cardiovascular disease ; Cohort Studies ; Cross-Sectional Studies ; Drug therapy ; epidemiology ; Female ; Fibrosis - blood ; Galectin 3 - blood ; Heart ; Heart attacks ; heart failure ; Heart Failure - blood ; Heart Failure - mortality ; Heart failure, cardiogenic pulmonary edema, cardiac enlargement ; Heart Ventricles - physiopathology ; Humans ; Incidence ; Internal Medicine ; Longitudinal Studies ; Male ; Medical sciences ; Middle Aged ; Mortality ; Myocardium - pathology ; Natriuretic Peptide, Brain - blood ; Prognosis ; Prospective Studies ; Risk Factors ; Stroke Volume
Is Part Of: Journal of the American College of Cardiology, 2012-10, Vol.60 (14), p.1249-1256
Description: Objectives The aim of this study was to examine the relation of galectin-3 (Gal-3), a marker of cardiac fibrosis, with incident heart failure (HF) in the community. Background Gal-3 is an emerging prognostic biomarker in HF, and experimental studies suggest that Gal-3 is an important mediator of cardiac fibrosis. Whether elevated Gal-3 concentrations precede the development of HF is unknown. Methods Gal-3 concentrations were measured in 3,353 participants in the Framingham Offspring Cohort (mean age 59 years; 53% women). The relation of Gal-3 to incident HF was assessed using proportional hazards regression. Results Gal-3 was associated with increased left ventricular mass in age-adjusted and sex-adjusted analyses (p = 0.001); this association was attenuated in multivariate analyses (p = 0.06). A total of 166 participants developed incident HF and 468 died during a mean follow-up period of 11.2 years. Gal-3 was associated with risk for incident HF (hazard ratio [HR]: 1.28 per 1 SD increase in log Gal-3; 95% confidence interval [CI]: 1.14 to 1.43; p < 0.0001) and remained significant after adjustment for clinical variables and B-type natriuretic peptide (HR: 1.23; 95% CI: 1.04 to 1.47; p = 0.02). Gal-3 was also associated with risk for all-cause mortality (multivariable-adjusted HR: 1.15; 95% CI: 1.04 to 1.28; p = 0.01). The addition of Gal-3 to clinical factors resulted in negligible changes to the C-statistic and minor improvements in net reclassification improvement. Conclusions Higher concentration of Gal-3, a marker of cardiac fibrosis, is associated with increased risk for incident HF and mortality. Future studies evaluating the role of Gal-3 in cardiac remodeling may provide further insights into the role of Gal-3 in the pathophysiology of HF.
Publisher: New York, NY: Elsevier Inc
Language: English
Identifier: ISSN: 0735-1097
EISSN: 1558-3597
DOI: 10.1016/j.jacc.2012.04.053
PMID: 22939561
CODEN: JACCDI
Source: Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
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Galectin-3, a Marker of Cardiac Fibrosis, Predicts Incident Heart Failure in the Community

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