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German version of the chronic urticaria quality-of-life questionnaire: factor analysis, validation, and initial clinical findings

Allergy, 2009-06, Vol.64 (6), p.927-936 [Peer Reviewed Journal]

2009 The Authors. Journal compilation © 2009 Blackwell Munksgaard ;2009 INIST-CNRS ;Journal compilation © 2009 Blackwell Munksgaard ;ISSN: 0105-4538 ;EISSN: 1398-9995 ;DOI: 10.1111/j.1398-9995.2008.01920.x ;PMID: 19453340 ;CODEN: LLRGDY

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Title:
German version of the chronic urticaria quality-of-life questionnaire: factor analysis, validation, and initial clinical findings
Author: Młynek, A ; Magerl, M ; Hanna, M ; Lhachimi, S ; Baiardini, I ; Canonica, G.W ; Brzoza, Z ; Kasperska-Zajac, A ; Rogala, B ; Zalewska-Janowska, A ; Zuberbier, T ; Maurer, M
Subjects: Adult ; Aged ; Allergic diseases ; Biological and medical sciences ; Chronic Disease ; chronic urticaria quality-of-life ; chronic urticaria quality-of-life questionnaire ; Dermatology ; Dermatology Life Quality Index ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Immunopathology ; Male ; Medical sciences ; Middle Aged ; Principal Component Analysis ; Pruritus - psychology ; Quality of Life ; questionnaire validation ; Questionnaires ; Regression Analysis ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Skin allergic diseases. Stinging insect allergies ; Skin diseases ; Skindex-29 ; Sleep ; Surveys and Questionnaires ; Urticaria - psychology
Is Part Of: Allergy, 2009-06, Vol.64 (6), p.927-936
Description: Chronic urticaria (CU) is a common skin disorder that causes a substantial burden on patients' quality-of-life (QoL). The aim of this work was to generate and validate a German version of the Chronic Urticaria Quality of Life Questionnaire (CU-Q₂oL) and to provide reference assessments of QoL. The Italian CU-Q₂oL was translated into German and administered to 157 CU patients. They also completed two well-established general dermatology QoL questionnaires, the Dermatology Life Quality Index (DLQI) and Skindex-29. Factor analysis was used to identify scales of the German CU-Q₂oL. Correlation to the DLQI and Skindex-29 was used for validation. Multiple linear regression was used to determine which patient characteristics were associated with which dimensions of QoL. The factor analysis identified six scales of the German CU-Q₂oL: functioning, sleep, itching/embarrassment, mental status, swelling/eating, and limits looks, which accounted for 70% of the data variance. Five of these six scales showed good internal consistency, and another five demonstrated convergent validity. On a percentile scale, they had these median CU-Q₂oL scores: 29 functioning, 44 sleep, 50 itching/embarrassment, 50 mental status, 31 swelling/eating, 31 limits looks. Disease severity significantly predicted scores on all scales. Age predicted functioning, sleep, itching/embarrassment, and swelling/eating. Sex predicted itching/embarrassment and limits looks. This study yielded a robust validation of the German version of the CU-Q₂oL. It confirmed previous studies that CU has a clinically meaningful burden on QoL, especially for sleep and mental health, and that women are more severely affected by pruritus. The German CU-Q₂oL should be widely adopted in clinical research on the treatment of CU.
Publisher: Oxford, UK: Oxford, UK : Blackwell Publishing Ltd
Language: English
Identifier: ISSN: 0105-4538
EISSN: 1398-9995
DOI: 10.1111/j.1398-9995.2008.01920.x
PMID: 19453340
CODEN: LLRGDY
Source: MEDLINE
Alma/SFX Local Collection

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German version of the chronic urticaria quality-of-life questionnaire: factor analysis, validation, and initial clinical findings

2009 The Authors. Journal compilation © 2009 Blackwell Munksgaard ;2009 INIST-CNRS ;Journal compilation © 2009 Blackwell Munksgaard ;ISSN: 0105-4538 ;EISSN: 1398-9995 ;DOI: 10.1111/j.1398-9995.2008.01920.x ;PMID: 19453340 ;CODEN: LLRGDY

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