skip to main content
Guest
My Research
My Account
Sign out
Sign in
This feature requires javascript
Library Search
Find Databases
Browse Search
E-Journals A-Z
E-Books A-Z
Citation Linker
Help
Language:
English
Vietnamese
This feature required javascript
This feature requires javascript
Primo Search
All Library Resources
All
Course Materials
Course Materials
Search For:
Clear Search Box
Search in:
All Library Resources
Or hit Enter to replace search target
Or select another collection:
Search in:
All Library Resources
Search in:
Print Resources
Search in:
Digital Resources
Search in:
Online E-Resources
Advanced Search
Browse Search
This feature requires javascript
Search Limited to:
Search Limited to:
Resource type
criteria input
anywhere in the record
in the title
as author/creator
in subject
Full Text
ISBN
ISSN
TOC
Keyword
Field
Show Results with:
in the title
Show Results with:
anywhere in the record
in the title
as author/creator
in subject
Full Text
ISBN
ISSN
TOC
Keyword
Field
Show Results with:
criteria input
that contain my query words
with my exact phrase
starts with
Show Results with:
Search type Index
criteria input
AND
OR
NOT
This feature requires javascript
Myc suppresses male–male courtship in Drosophila
The EMBO journal, 2022-04, Vol.41 (7), p.e109905-n/a
[Peer Reviewed Journal]
2022 The Authors ;2022 The Authors. ;2022 EMBO ;ISSN: 0261-4189 ;EISSN: 1460-2075 ;DOI: 10.15252/embj.2021109905 ;PMID: 35167135
Full text available
Citations
Cited by
View Online
Details
Recommendations
Reviews
Times Cited
External Links
This feature requires javascript
Actions
Add to My Research
Remove from My Research
E-mail
Print
Permalink
Citation
EasyBib
EndNote
RefWorks
Delicious
Export RIS
Export BibTeX
This feature requires javascript
Title:
Myc suppresses male–male courtship in Drosophila
Author:
Pan, Yu
;
Li, Wanzhen
;
Deng, Zhu
;
Sun, Yihao
;
Ma, Xianjue
;
Liang, Ruijuan
;
Guo, Xiaowei
;
Sun, Ying
;
Li, Wenzhe
;
Jiao, Renjie
;
Xue, Lei
Subjects:
Animals
;
Aromatic-L-amino-acid decarboxylase
;
Binding
;
Courtship
;
Ddc
;
Depletion
;
Dihydroxyphenylalanine
;
Dopamine
;
Dopamine - metabolism
;
Dopamine receptors
;
Dopaminergic Neurons - metabolism
;
Drosophila
;
Drosophila - physiology
;
Drosophila melanogaster - metabolism
;
Drosophila Proteins - genetics
;
Drosophila Proteins - metabolism
;
Fruit flies
;
Gene deletion
;
Genetic factors
;
Genetic screening
;
Genomes
;
Insects
;
Male
;
Males
;
male–male courtship
;
Mutation
;
Myc
;
Myc protein
;
Natural selection
;
Nervous system
;
Neurons
;
Sexual behavior
;
Transcription
Is Part Of:
The EMBO journal, 2022-04, Vol.41 (7), p.e109905-n/a
Description:
Despite strong natural selection on species, same‐sex sexual attraction is widespread across animals, yet the underlying mechanisms remain elusive. Here, we report that the proto‐oncogene Myc is required in dopaminergic neurons to inhibit Drosophila male–male courtship. Loss of Myc, either by mutation or neuro‐specific knockdown, induced males’ courtship propensity toward other males. Our genetic screen identified DOPA decarboxylase (Ddc) as a downstream target of Myc. While loss of Ddc abrogated Myc depletion‐induced male–male courtship, Ddc overexpression sufficed to trigger such behavior. Furthermore, Myc‐depleted males exhibited elevated dopamine level in a Ddc‐dependent manner, and their male–male courtship was blocked by depleting the dopamine receptor DopR1. Moreover, Myc directly inhibits Ddc transcription by binding to a target site in the Ddc promoter, and deletion of this site by genome editing was sufficient to trigger male–male courtship. Finally, drug‐mediated Myc depletion in adult neurons by GeneSwitch technique sufficed to elicit male–male courtship. Thus, this study uncovered a novel function of Myc in preventing Drosophila male–male courtship, and supports the crucial roles of genetic factors in inter‐male sexual behavior. Synopsis Drosophila Myc is required in the nervous system to prevent male–male courtship in a DOPA decarboxylase (Ddc)‐dependent manner, and drug‐mediated Myc depletion in adult neurons suffices to elicit male–male courtship. Drosophila Myc is required in the nervous system to prevent male–male courtship. DOPA decarboxylase (Ddc) is necessary and sufficient for loss‐of‐Myc‐induced male–male courtship. Myc directly inhibits Ddc transcription by binding to a Myc target site (E‐box) in the Ddc promoter. Drug‐mediated Myc depletion in adult neurons suffices to elicit male–male courtship. The proto‐oncogene Myc is specifically required in dopaminergic neurons to repress DOPA decarboxylase transcription, reducing the levels of dopamine and suppressing male–male courtship in flies.
Publisher:
England: Blackwell Publishing Ltd
Language:
English
Identifier:
ISSN: 0261-4189
EISSN: 1460-2075
DOI: 10.15252/embj.2021109905
PMID: 35167135
Source:
Geneva Foundation Free Medical Journals
MEDLINE
PubMed Central
Alma/SFX Local Collection
This feature requires javascript
This feature requires javascript
Back to results list
This feature requires javascript
This feature requires javascript
Searching Remote Databases, Please Wait
Searching for
in
scope:(TDTS),scope:(SFX),scope:(TDT),scope:(SEN),primo_central_multiple_fe
Show me what you have so far
This feature requires javascript
This feature requires javascript