Language:

Functional and morphological assessment of ocular structures and follow-up of patients with early-stage Parkinson’s disease

International ophthalmology, 2019-06, Vol.39 (6), p.1255-1262 [Peer Reviewed Journal]

Springer Science+Business Media B.V., part of Springer Nature 2018 ;International Ophthalmology is a copyright of Springer, (2018). All Rights Reserved. ;ISSN: 0165-5701 ;EISSN: 1573-2630 ;DOI: 10.1007/s10792-018-0934-y ;PMID: 29744762

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Functional and morphological assessment of ocular structures and follow-up of patients with early-stage Parkinson’s disease
Author: Hasanov, Samir ; Demirkilinc Biler, Elif ; Acarer, Ahmet ; Akkın, Cezmi ; Colakoglu, Zafer ; Uretmen, Onder
Subjects: Acuity ; Adult ; Aged ; Case-Control Studies ; Color vision ; Color Vision - physiology ; Contrast Sensitivity - physiology ; Disease control ; Evoked Potentials, Visual - physiology ; Female ; Field tests ; Follow-Up Studies ; Humans ; Latency ; Macula Lutea - pathology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Morphology ; Nerve Fibers - pathology ; Ophthalmology ; Optic nerve ; Optic Nerve - physiopathology ; Original Paper ; Parkinson Disease - physiopathology ; Parkinsons disease ; Patients ; Prospective Studies ; Quadrants ; Retina ; Retina - physiopathology ; Retinal Ganglion Cells - pathology ; Sensitivity ; Sensitivity analysis ; Structure-function relationships ; Thickness ; Tomography, Optical Coherence ; Visual Acuity ; Visual evoked potentials ; Visual field ; Visual fields ; Visual Fields - physiology ; Visual observation ; Visual pathways ; Visual Pathways - physiopathology
Is Part Of: International ophthalmology, 2019-06, Vol.39 (6), p.1255-1262
Description: Purpose To evaluate and follow-up of functional and morphological changes of the optic nerve and ocular structures prospectively in patients with early-stage Parkinson’s disease. Materials and methods Nineteen patients with a diagnosis of early-stage Parkinson’s disease and 19 age-matched healthy controls were included in the study. All participants were examined minimum three times at the intervals of at least 6 month following initial examination. Pattern visually evoked potentials (VEP), contrast sensitivity assessments at photopic conditions, color vision tests with Ishihara cards and full-field visual field tests were performed in addition to measurement of retinal nerve fiber layer (RNFL) thickness of four quadrants (top, bottom, nasal, temporal), central and mean macular thickness and macular volumes. Results Best corrected visual acuity was observed significantly lower in study group within all three examinations. Contrast sensitivity values of the patient group were significantly lower in all spatial frequencies. P100 wave latency of VEP was significantly longer, and amplitude was lower in patient group; however, significant deterioration was not observed during the follow-up. Although average peripapillary RNFL thickness was not significant between groups, RNFL thickness in the upper quadrant was thinner in the patient group. While there was no difference in terms of mean macular thickness and total macular volume values between the groups initially, a significant decrease occurred in the patient group during the follow-up. During the initial and follow-up process, a significant deterioration in visual field was observed in the patient group. Conclusion Structural and functional disorders shown as electro-physiologically and morphologically exist in different parts of visual pathways in early-stage Parkinson’s disease.
Publisher: Dordrecht: Springer Netherlands
Language: English
Identifier: ISSN: 0165-5701
EISSN: 1573-2630
DOI: 10.1007/s10792-018-0934-y
PMID: 29744762
Source: MEDLINE
ProQuest Central

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Functional and morphological assessment of ocular structures and follow-up of patients with early-stage Parkinson’s disease

Springer Science+Business Media B.V., part of Springer Nature 2018 ;International Ophthalmology is a copyright of Springer, (2018). All Rights Reserved. ;ISSN: 0165-5701 ;EISSN: 1573-2630 ;DOI: 10.1007/s10792-018-0934-y ;PMID: 29744762

Searching Remote Databases, Please Wait