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Predicting tenocyte expression profiles and average molecular concentrations in Achilles tendon ECM from tissue strain and fiber damage

Biomechanics and modeling in mechanobiology, 2017-08, Vol.16 (4), p.1329-1348 [Peer Reviewed Journal]

Springer-Verlag Berlin Heidelberg 2017 ;Biomechanics and Modeling in Mechanobiology is a copyright of Springer, 2017. ;ISSN: 1617-7959 ;EISSN: 1617-7940 ;DOI: 10.1007/s10237-017-0890-x ;PMID: 28289916

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Title:
Predicting tenocyte expression profiles and average molecular concentrations in Achilles tendon ECM from tissue strain and fiber damage
Author: Mehdizadeh, Arash ; Gardiner, Bruce S. ; Lavagnino, Michael ; Smith, David W.
Subjects: Achilles tendon ; Achilles Tendon - physiology ; Achilles Tendon - physiopathology ; ADAM protein ; Biological and Medical Physics ; Biomechanics ; Biomedical Engineering and Bioengineering ; Biophysics ; Collagen (type I) ; Damage ; Electrochemical machining ; Engineering ; Extracellular matrix ; Extracellular Matrix - chemistry ; Extracellular Matrix - physiology ; Fibers ; Fibroblasts ; Gene expression ; Gene Expression Profiling ; Gene Expression Regulation ; Homeostasis ; Humans ; In vitro methods and tests ; Interleukin ; Interleukin 1 ; Mathematical models ; Matrix metalloproteinase ; Mechanical loading ; Metalloproteinase ; Models, Biological ; Original Paper ; Predictions ; Scaling up ; Signal Transduction ; Space life sciences ; Stimulation ; Strain ; Tendinopathy - physiopathology ; Tendons ; Tendons - physiology ; Tendons - physiopathology ; Tenocytes - cytology ; Tenocytes - physiology ; Theoretical and Applied Mechanics ; Thrombospondin
Is Part Of: Biomechanics and modeling in mechanobiology, 2017-08, Vol.16 (4), p.1329-1348
Description: In this study, we propose a method for quantitative prediction of changes in concentrations of a number of key signaling, structural and effector molecules within the extracellular matrix of tendon. To achieve this, we introduce the notion of elementary cell responses (ECRs). An ECR defines a normal reference secretion profile of a molecule by a tenocyte in response to the tenocyte’s local strain. ECRs are then coupled with a model for mechanical damage of tendon collagen fibers at different straining conditions of tendon and then scaled up to the tendon tissue level for comparison with experimental observations. Specifically, our model predicts relative changes in ECM concentrations of transforming growth factor beta, interleukin 1 beta, collagen type I, glycosaminoglycan, matrix metalloproteinase 1 and a disintegrin and metalloproteinase with thrombospondin motifs 5, with respect to tendon straining conditions that are consistent with the observations in the literature. In good agreement with a number of in vivo and in vitro observations, the model provides a logical and parsimonious explanation for how excessive mechanical loading of tendon can lead to under-stimulation of tenocytes and a degenerative tissue profile, which may well have bearing on a better understanding of tendon homeostasis and the origin of some tendinopathies.
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
Language: English
Identifier: ISSN: 1617-7959
EISSN: 1617-7940
DOI: 10.1007/s10237-017-0890-x
PMID: 28289916
Source: MEDLINE
ProQuest Central

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Predicting tenocyte expression profiles and average molecular concentrations in Achilles tendon ECM from tissue strain and fiber damage

Springer-Verlag Berlin Heidelberg 2017 ;Biomechanics and Modeling in Mechanobiology is a copyright of Springer, 2017. ;ISSN: 1617-7959 ;EISSN: 1617-7940 ;DOI: 10.1007/s10237-017-0890-x ;PMID: 28289916

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