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B cells in autoimmune and neurodegenerative central nervous system diseases

Nature reviews. Neuroscience, 2019-12, Vol.20 (12), p.728-745 [Peer Reviewed Journal]

COPYRIGHT 2019 Nature Publishing Group ;Copyright Nature Publishing Group Dec 2019 ;ISSN: 1471-003X ;EISSN: 1471-0048 ;DOI: 10.1038/s41583-019-0233-2 ;PMID: 31712781

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Title:
B cells in autoimmune and neurodegenerative central nervous system diseases
Author: Sabatino, Jr, Joseph J ; Pröbstel, Anne-Katrin ; Zamvil, Scott S
Subjects: Adaptive Immunity - drug effects ; Adaptive Immunity - immunology ; Alzheimer's disease ; Animals ; Antigen presentation ; Autoantibodies ; Autoimmune Diseases - drug therapy ; Autoimmune Diseases - immunology ; Autoimmune Diseases - pathology ; Autoimmunity ; B cells ; B-Lymphocytes - drug effects ; B-Lymphocytes - immunology ; B-Lymphocytes - pathology ; Care and treatment ; Central nervous system ; Central nervous system diseases ; Central Nervous System Diseases - drug therapy ; Central Nervous System Diseases - immunology ; Central Nervous System Diseases - pathology ; Cytokines ; Development and progression ; Disease ; Humans ; Immune response ; Immunity ; Immunosuppressive Agents - pharmacology ; Immunosuppressive Agents - therapeutic use ; Inflammation ; Lymphocytes B ; Lymphocytes T ; Movement disorders ; Multiple sclerosis ; Nervous system ; Nervous system diseases ; Neurodegenerative diseases ; Neurodegenerative Diseases - drug therapy ; Neurodegenerative Diseases - immunology ; Neurodegenerative Diseases - pathology ; Neuromyelitis ; Parkinson's disease ; Pathogenesis ; T cells
Is Part Of: Nature reviews. Neuroscience, 2019-12, Vol.20 (12), p.728-745
Description: B cells are essential components of the adaptive immune system and have important roles in the pathogenesis of several central nervous system (CNS) diseases. Besides producing antibodies, B cells perform other functions, including antigen presentation to T cells, production of proinflammatory cytokines and secretion of anti-inflammatory cytokines that limit immune responses. B cells can contribute to CNS disease either through their actions in the periphery (meaning that they have an 'outside-in' effect on CNS immunopathology) or following their compartmentalization within the CNS. The success of B cell-depleting therapy in patients with multiple sclerosis and CNS diseases with an autoantibody component, such as neuromyelitis optica spectrum disorder and autoimmune encephalitides, has underscored the role of B cells in both cellular and humoral-mediated CNS conditions. Emerging evidence suggests B cells also contribute to the pathogenesis of neurodegenerative diseases, including Alzheimer disease and Parkinson disease. Advancing our understanding of the role of B cells in neuroinflammatory and neurodegenerative diseases could lead to novel therapeutic approaches.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1471-003X
EISSN: 1471-0048
DOI: 10.1038/s41583-019-0233-2
PMID: 31712781
Source: ProQuest One Psychology
MEDLINE
ProQuest Central

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B cells in autoimmune and neurodegenerative central nervous system diseases

COPYRIGHT 2019 Nature Publishing Group ;Copyright Nature Publishing Group Dec 2019 ;ISSN: 1471-003X ;EISSN: 1471-0048 ;DOI: 10.1038/s41583-019-0233-2 ;PMID: 31712781

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