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Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study

Intensive care medicine, 2020-10, Vol.46 (10), p.1863-1872 [Peer Reviewed Journal]

Springer-Verlag GmbH Germany, part of Springer Nature 2020 ;COPYRIGHT 2020 Springer ;Springer-Verlag GmbH Germany, part of Springer Nature 2020. ;ISSN: 0342-4642 ;EISSN: 1432-1238 ;DOI: 10.1007/s00134-020-06211-2 ;PMID: 32816098

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Title:
Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study
Author: Xie, Jianfeng ; Wu, Wenjuan ; Li, Shusheng ; Hu, Yu ; Hu, Ming ; Li, Jinxiu ; Yang, Yi ; Huang, Tingrong ; Zheng, Kun ; Wang, Yishan ; Kang, Hanyujie ; Huang, Yingzi ; Jiang, Li ; Zhang, Wei ; Zhong, Ming ; Sang, Ling ; Zheng, Xia ; Pan, Chun ; Zheng, Ruiqiang ; Li, Xuyan ; Tong, Zhaohui ; Qiu, Haibo ; Du, Bin
Subjects: Aged ; Albumins ; Anesthesiology ; Betacoronavirus ; Central nervous system ; China ; China - epidemiology ; Communicable diseases ; Comorbidity ; Comparative analysis ; Coronaviridae ; Coronavirus Infections - complications ; Coronavirus Infections - epidemiology ; Coronavirus Infections - mortality ; Coronavirus Infections - virology ; Coronaviruses ; COVID-19 ; Creatinine ; Critical Care Medicine ; Critical Illness ; Dimers ; Disease Outbreaks ; Emergency Medicine ; Failure ; Female ; Hospital patients ; Humans ; Infectious diseases ; Intensive ; Intensive care ; Intensive Care Units ; Kidney Diseases - epidemiology ; Kidney Diseases - etiology ; Laboratories ; Male ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Middle Aged ; Mortality ; Nervous System Diseases - epidemiology ; Nervous System Diseases - etiology ; Original ; Pain Medicine ; Pandemics ; Patient outcomes ; Patients ; Pediatrics ; Pneumology/Respiratory System ; Pneumonia, Viral - complications ; Pneumonia, Viral - epidemiology ; Pneumonia, Viral - mortality ; Pneumonia, Viral - virology ; Proportional Hazards Models ; Public health ; Regression analysis ; Renal function ; Respiratory Insufficiency - epidemiology ; Respiratory Insufficiency - etiology ; Retrospective Studies ; Risk analysis ; Risk Factors ; SARS-CoV-2 ; Shock - epidemiology ; Shock - etiology ; Signs and symptoms ; Thrombocytopenia ; Thrombocytopenia - epidemiology ; Thrombocytopenia - etiology ; Viral diseases
Is Part Of: Intensive care medicine, 2020-10, Vol.46 (10), p.1863-1872
Description: Purpose An ongoing outbreak of coronavirus disease 2019 (COVID-19) emerged in Wuhan since December 2019 and spread globally. However, information about critically ill patients with COVID-19 is still limited. We aimed to describe the clinical characteristics and outcomes of critically ill patients with COVID-19 and figure out the risk factors of mortality. Methods We extracted data retrospectively regarding 733 critically ill adult patients with laboratory-confirmed COVID-19 from 19 hospitals in China through January 1 to February 29, 2020. Demographic data, symptoms, laboratory values, comorbidities, treatments, and clinical outcomes were collected. The primary outcome was 28-day mortality. Data were compared between survivors and non-survivors. Results Of the 733 patients included in the study, the median (IQR) age was 65 (56–73) years and 256 (34.9%) were female. Among these patients, the median (IQR) APACHE II score was 10 (7 to 14) and 28-day mortality was 53.8%. Respiratory failure was the most common organ failure (597 [81.5%]), followed by shock (20%), thrombocytopenia (18.8%), central nervous system (8.6%) and renal dysfunction (8%). Multivariate Cox regression analysis showed that older age, malignancies, high APACHE II score, high d -dimer level, low PaO 2 /FiO 2 level, high creatinine level, high hscTnI level and low albumin level were independent risk factors of 28-day mortality in critically ill patients with COVID-19. Conclusion In this case series of critically ill patients with COVID-19 who were admitted into the ICU, more than half patients died at day 28. The higher percentage of organ failure in these patients indicated a significant demand for critical care resources.
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
Language: English
Identifier: ISSN: 0342-4642
EISSN: 1432-1238
DOI: 10.1007/s00134-020-06211-2
PMID: 32816098
Source: MEDLINE
ProQuest Central

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Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study

Springer-Verlag GmbH Germany, part of Springer Nature 2020 ;COPYRIGHT 2020 Springer ;Springer-Verlag GmbH Germany, part of Springer Nature 2020. ;ISSN: 0342-4642 ;EISSN: 1432-1238 ;DOI: 10.1007/s00134-020-06211-2 ;PMID: 32816098

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