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Drug repurposing: progress, challenges and recommendations

Nature reviews. Drug discovery, 2019-01, Vol.18 (1), p.41-58 [Peer Reviewed Journal]

COPYRIGHT 2019 Nature Publishing Group ;Copyright Nature Publishing Group Jan 2019 ;ISSN: 1474-1776 ;EISSN: 1474-1784 ;DOI: 10.1038/nrd.2018.168 ;PMID: 30310233

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Title:
Drug repurposing: progress, challenges and recommendations
Author: Pushpakom, Sudeep ; Iorio, Francesco ; Eyers, Patrick A ; Escott, K Jane ; Hopper, Shirley ; Wells, Andrew ; Doig, Andrew ; Guilliams, Tim ; Latimer, Joanna ; McNamee, Christine ; Norris, Alan ; Sanseau, Philippe ; Cavalla, David ; Pirmohamed, Munir
Subjects: Drug Discovery ; Drug Industry ; Drug Repositioning - standards ; Drugs ; Humans ; Methods ; Natural language processing ; Pharmaceutical industry ; Pharmacology ; Planning
Is Part Of: Nature reviews. Drug discovery, 2019-01, Vol.18 (1), p.41-58
Description: Given the high attrition rates, substantial costs and slow pace of new drug discovery and development, repurposing of 'old' drugs to treat both common and rare diseases is increasingly becoming an attractive proposition because it involves the use of de-risked compounds, with potentially lower overall development costs and shorter development timelines. Various data-driven and experimental approaches have been suggested for the identification of repurposable drug candidates; however, there are also major technological and regulatory challenges that need to be addressed. In this Review, we present approaches used for drug repurposing (also known as drug repositioning), discuss the challenges faced by the repurposing community and recommend innovative ways by which these challenges could be addressed to help realize the full potential of drug repurposing.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1474-1776
EISSN: 1474-1784
DOI: 10.1038/nrd.2018.168
PMID: 30310233
Source: MEDLINE
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Drug repurposing: progress, challenges and recommendations

COPYRIGHT 2019 Nature Publishing Group ;Copyright Nature Publishing Group Jan 2019 ;ISSN: 1474-1776 ;EISSN: 1474-1784 ;DOI: 10.1038/nrd.2018.168 ;PMID: 30310233

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