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Antifungal activity and mode of action of silver nano-particles on Candida albicans

Biometals, 2009-04, Vol.22 (2), p.235-242 [Peer Reviewed Journal]

Springer Science+Business Media, LLC. 2008 ;Springer Science+Business Media, LLC. 2009 ;ISSN: 0966-0844 ;EISSN: 1572-8773 ;DOI: 10.1007/s10534-008-9159-2 ;PMID: 18769871

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Title:
Antifungal activity and mode of action of silver nano-particles on Candida albicans
Author: Kim, Keuk-Jun ; Sung, Woo Sang ; Suh, Bo Kyoung ; Moon, Seok-Ki ; Choi, Jong-Soo ; Kim, Jong Guk ; Lee, Dong Gun
Subjects: Antifungal Agents - chemistry ; Antifungal Agents - pharmacology ; Biochemistry ; Biomedical and Life Sciences ; Candida albicans ; Candida albicans - drug effects ; Candida albicans - metabolism ; Cell Biology ; Cell Cycle ; Cell Membrane - drug effects ; Erythrocytes ; Erythrocytes - drug effects ; Flow Cytometry - methods ; Fungi ; Glucose - metabolism ; Humans ; Life Sciences ; Medicine/Public Health ; Metal Nanoparticles - chemistry ; Microbiology ; Microscopy, Electron, Transmission - methods ; Nanoparticles ; Nanotechnology - methods ; Pharmacology/Toxicology ; Plant Physiology ; Saccharomyces cerevisiae - metabolism ; Silver ; Silver - chemistry ; Trehalose - metabolism ; Trichosporon - metabolism
Is Part Of: Biometals, 2009-04, Vol.22 (2), p.235-242
Description: In this study, the antifungal effects of silver nano-particles (nano-Ag) and their mode of action were investigated. Nano-Ag showed antifungal effects on fungi tested with low hemolytic effects against human erythrocytes. To elucidate the antifungal mode of action of nano-Ag, flow cytometry analysis, a glucose-release test, transmission electron microscopy (TEM) and the change in membrane dynamics using 1,6-diphenyl-1,3,5-hexatriene (DPH), as a plasma membrane probe, were performed with Candida albicans. The results suggest nano-Ag may exert an antifungal activity by disrupting the structure of the cell membrane and inhibiting the normal budding process due to the destruction of the membrane integrity. The present study indicates nano-Ag has considerable antifungal activity, deserving further investigation for clinical applications.
Publisher: Dordrecht: Dordrecht : Springer Netherlands
Language: English;Dutch
Identifier: ISSN: 0966-0844
EISSN: 1572-8773
DOI: 10.1007/s10534-008-9159-2
PMID: 18769871
Source: MEDLINE
Alma/SFX Local Collection
ProQuest Central

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Antifungal activity and mode of action of silver nano-particles on Candida albicans

Springer Science+Business Media, LLC. 2008 ;Springer Science+Business Media, LLC. 2009 ;ISSN: 0966-0844 ;EISSN: 1572-8773 ;DOI: 10.1007/s10534-008-9159-2 ;PMID: 18769871

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