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Predictors for functional and anatomic outcomes in macular edema secondary to non-infectious uveitis

PloS one, 2019-01, Vol.14 (1), p.e0210799-e0210799 [Peer Reviewed Journal]

COPYRIGHT 2019 Public Library of Science ;COPYRIGHT 2019 Public Library of Science ;2019 Matas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;cc-by (c) Matas, Jessica et al., 2019 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/3.0/es ;2019 Matas et al 2019 Matas et al ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0210799 ;PMID: 30677041

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Title:
Predictors for functional and anatomic outcomes in macular edema secondary to non-infectious uveitis
Author: Matas, Jessica ; Llorenç, Victor ; Fonollosa, Alex ; Esquinas, Cristina ; Diaz-Valle, David ; Berasategui, Barbara ; Mesquida, Marina ; Artaraz, Joseba ; Rios, Jose ; Adan, Alfredo
Rosenbaum, James T.
Subjects: Acuity ; Adult ; Adults ; Aged ; Aged, 80 and over ; Analysis ; Anterior chamber ; Biology and Life Sciences ; Biomedical research ; Coherence (Optics) ; Cystoid macular edema ; Demographics ; Edema ; Exploration ; Eye ; Eye (anatomy) ; Eye diseases ; Female ; Follow-Up Studies ; Fovea Centralis - diagnostic imaging ; Fovea Centralis - pathology ; High definition ; Hospitals ; Humans ; Infectious diseases ; Macular Edema - diagnostic imaging ; Macular Edema - etiology ; Macular Edema - physiopathology ; Male ; Medical prognosis ; Medical research ; Medicine and Health Sciences ; Middle Aged ; Optical Coherence Tomography ; Outcome and process assessment (Health Care) ; Outcome and process assessment (Medical care) ; Outcome Assessment, Health Care ; Prognosis ; Prospective Studies ; Thickening ; Tomography ; Tomography, Optical Coherence ; Uveitis ; Uveitis - complications ; Uveïtis ; Visual Acuity ; Visual aspects ; Visual impairment ; Working groups ; Young Adult
Is Part Of: PloS one, 2019-01, Vol.14 (1), p.e0210799-e0210799
Description: We aimed to investigate predictive factors for visual and anatomic outcomes in patients with macular edema secondary to non-infectious uveitis. We conducted a multicenter, prospective, observational, 12-month follow-up study. Participants included in the study were adults with non-infectious uveitic macular edema (UME), defined as central subfoveal thickness (CST) of >300 μm as measured by spectral domain optical coherence tomography (SD-OCT) and fluid in the macula. Demographic, clinical and tomographic data was recorded at baseline, 1, 3, 6 and 12 months. Foveal-centered SD-OCT exploration was set as the gold-standard determination of UME using a standard Macular Cube 512x128 A-scan, within a 6 x 6 mm2 area, and the Enhanced High Definition Single-Line Raster. To assess favorable prognosis, the main outcomes analyzed were the best-corrected visual acuity (BCVA) and the CST. Favorable prognosis was defined as sustained improvement of BCVA (2 lines of gain of the Snellen scale) and CST (decrease of 20% of the initial value or <300 μm) within a 12 month period. Fifty-six eyes were analyzed. The number of eyes with sustained improvement in the CST was 48 (86.2%), against 23 (41.1%) eyes with sustained improvement in BCVA. Favorable prognosis, as defined above, was observed in 18 (32.1%) eyes. UME prognosis was negatively correlated with baseline foveal thickening, alteration in the vitreo-macular interface and cystoid macular edema. In contrast, bilaterally, systemic disease and the presence of anterior chamber cells were predictive of favorable prognosis. Available treatment modalities in UME may avoid chronic UME and improve anatomic outcome. However, the proportion of functional amelioration observed during 12 months of follow-up is lower. Thicker CST, alteration in the vitreo-macular interface and cystoid macular edema may denote less favorable prognosis. Conversely, bilaterally, systemic disease and anterior chamber cells may be associated with favorable prognosis in UME.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1932-6203
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0210799
PMID: 30677041
Source: Recercat
GFMER Free Medical Journals
MEDLINE
PubMed Central
Public Library of Science (PLoS)
ProQuest Central
DOAJ Directory of Open Access Journals

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Predictors for functional and anatomic outcomes in macular edema secondary to non-infectious uveitis

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