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Effect of behavioral weight‐loss program on biomarkers of cardiometabolic disease risk: Heart Health Study randomized trial

Obesity (Silver Spring, Md.), 2023-02, Vol.31 (2), p.338-349 [Peer Reviewed Journal]

2023 The Obesity Society. ;Copyright Blackwell Publishing Ltd. Feb 2023 ;ISSN: 1930-7381 ;EISSN: 1930-739X ;DOI: 10.1002/oby.23618 ;PMID: 36621902

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  • Title:
    Effect of behavioral weight‐loss program on biomarkers of cardiometabolic disease risk: Heart Health Study randomized trial
  • Author: Collins, Katherine A. ; Kraus, William E. ; Rogers, Renee J. ; Hauser, Elizabeth R. ; Lang, Wei ; Jiang, Rong ; Schelbert, Erik B. ; Huffman, Kim M. ; Jakicic, John M.
  • Subjects: Adult ; Biomarkers ; Cardiovascular Diseases - prevention & control ; Humans ; Insulin Resistance ; NMR ; Nuclear magnetic resonance ; Obesity ; Obesity - metabolism ; Obesity - therapy ; Overweight - metabolism ; Overweight - therapy ; Weight Loss ; Weight Reduction Programs
  • Is Part Of: Obesity (Silver Spring, Md.), 2023-02, Vol.31 (2), p.338-349
  • Description: Objective This study aimed to determine whether novel biomarkers of cardiometabolic health improve in response to a 12‐month behavioral weight‐loss intervention and to compare benefits of diet alone with diet plus physical activity for these biomarkers. Methods Participants (N = 374) were randomized to either diet alone (DIET), diet plus 150 min/wk of prescribed moderate‐intensity physical activity (DIET + PA150), or diet plus 250 min/wk of prescribed moderate‐intensity physical activity (DIET + PA250). Biomarker concentrations were determined using nuclear magnetic resonance spectroscopy. Mixed models assessed for a time effect, group effect, or group by time interaction. Results All groups significantly improved body weight (time: p < 0.0001), Lipoprotein Insulin Resistance Index score (time: p < 0.0001), Diabetes Risk Index score (time: p < 0.0001), branched‐chain amino acid concentration (time: p < 0.0001), and GlycA concentration (time: p < 0.0001), with no group effect or group by time interactions. Conclusions All intervention groups prompted a notable beneficial change among biomarkers of insulin resistance and cardiometabolic health. However, the addition of at least moderate‐intensity physical activity to a diet‐only intervention did not provide any additional benefit. These findings highlight that an average weight loss of approximately 10% profoundly impacts biomarkers of insulin resistance and cardiometabolic disease in adults with overweight or obesity.
  • Publisher: United States: Blackwell Publishing Ltd
  • Language: English
  • Identifier: ISSN: 1930-7381
    EISSN: 1930-739X
    DOI: 10.1002/oby.23618
    PMID: 36621902
  • Source: AUTh Library subscriptions: ProQuest Central
    MEDLINE
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