skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Usefulness of the endotoxin activity assay to evaluate the degree of lung injury

Yonsei Medical Journal, 2014, 55(4), , pp.975-979 [Peer Reviewed Journal]

Copyright: Yonsei University College of Medicine 2014 2014 ;ISSN: 0513-5796 ;EISSN: 1976-2437 ;DOI: 10.3349/ymj.2014.55.4.975 ;PMID: 24954326

Full text available

Citations Cited by
  • Title:
    Usefulness of the endotoxin activity assay to evaluate the degree of lung injury
  • Author: Sakamoto, Yuichiro ; Inoue, Satoshi ; Iwamura, Takashi ; Yamashita, Tomoko ; Nakashima, Atsushi ; Koami, Hiroyuki ; Miike, Toru ; Yahata, Mayuko ; Imahase, Hisashi ; Goto, Akiko ; Narumi, Showgo ; Ohta, Miho ; Yamada, Chris-Kosuke
  • Subjects: Adult ; Aged ; Aged, 80 and over ; Cardiac Output - physiology ; Endotoxins - blood ; Female ; Humans ; Lung Injury - blood ; Lung Injury - diagnosis ; Lung Injury - physiopathology ; Male ; Middle Aged ; Original ; Pulmonary Edema - blood ; Pulmonary Edema - diagnosis ; Pulmonary Edema - physiopathology ; 의학일반
  • Is Part Of: Yonsei Medical Journal, 2014, 55(4), , pp.975-979
  • Description: It has been reported that the Pulse Contour Cardiac Output (PiCCO) is very useful mainly in the field of intensive care and treatment to grasp the pathophysiological conditions of pulmonary edema because of its capability of obtaining data such as Pulmonary Vascular Permeability Index (PVPI) and Extra Vascular Lung Water (EVLW). Furthermore, a high degree of usability of various markers has been reported for better understanding of the pathological conditions in cases with septicemia. The correlation between the cardiorespiratory status based upon the PiCCO monitor (EVLW and PVPI) and inflammatory markers including C reactive protein, procalcitonin (PC), and Endotoxin Activity Assay (EAA) were evaluated in 11 severe cases that required treatment with a respirator in an intensive care unit. The EAA values were significantly higher in patients with abnormal EVLW at 0.46±0.20 compared to the normal EVLW group at 0.21±0.19 (p=0.0064). In a similar fashion, patients with abnormal PVPI values tended to have higher PC levels at 18.9±21.8 compared to normal PVPI cases at 2.4±2.2 (p=0.0676). On the other hand, PVPI was significantly higher in the abnormal EAA group at 3.55±0.48 in comparison with the normal EAA group at 1.99±0.68 (p=0.0029). The abnormal EAA group tended to have higher PVPI values than the normal EAA group. The EAA is a measurement method designed to estimate the activity of endotoxins in the whole blood. Our results suggest that the EAA value, which had the greatest correlation with lung disorders diagnosed by the PiCCO monitoring, reflects inflammatory reactions predominantly in the lungs.
  • Publisher: Korea (South): Yonsei University College of Medicine
  • Language: English
  • Identifier: ISSN: 0513-5796
    EISSN: 1976-2437
    DOI: 10.3349/ymj.2014.55.4.975
    PMID: 24954326
  • Source: KoreaMed Synapse
    GFMER Free Medical Journals
    MEDLINE
    PubMed Central
    KoreaMed Open Access
    DOAJ Directory of Open Access Journals
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait