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Rifampicin-induced minimal change disease is improved after cessation of rifampicin without steroid therapy

Yonsei Medical Journal, 2015, 56(2), , pp.582-585 [Peer Reviewed Journal]

Copyright: Yonsei University College of Medicine 2015 2015 ;ISSN: 0513-5796 ;EISSN: 1976-2437 ;DOI: 10.3349/ymj.2015.56.2.582 ;PMID: 25684013

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Title:
Rifampicin-induced minimal change disease is improved after cessation of rifampicin without steroid therapy
Author: Park, Dong Hyuk ; Lee, Sul A ; Jeong, Hyeon Joo ; Yoo, Tae-Hyun ; Kang, Shin-Wook ; Oh, Hyung Jung
Subjects: Aged ; Antibiotics, Antitubercular - adverse effects ; Antibiotics, Antitubercular - therapeutic use ; Case Report ; Edema - etiology ; Female ; Humans ; Kidney Function Tests ; Kidney Glomerulus - pathology ; Nausea - etiology ; Nephrosis, Lipoid - chemically induced ; Nephrosis, Lipoid - pathology ; Proteinuria ; Remission Induction ; Rifampin - adverse effects ; Rifampin - therapeutic use ; Treatment Outcome ; Tuberculosis, Pleural - drug therapy ; 의학일반
Is Part Of: Yonsei Medical Journal, 2015, 56(2), , pp.582-585
Description: There are several reports to demonstrate that rifampicin, a major anti-tuberculosis agent, is associated with some adverse renal effects, with a few cases of rifampicin-induced minimal change disease (MCD). In the present case, a 68-year-old female presented with nausea, vomiting, foamy urine, general weakness and edema. She had been taking rifampicin for 4 weeks due to pleural tuberculosis. The patient had no proteinuria before the anti-tuberculosis agents were started, but urine tests upon admission showed heavy proteinuria with a 24-h urinary protein of 9.2 g/day, and serum creatinine, albumin, and total cholesterol levels were 1.36 mg/dL, 2.40 g/dL, and 283 mg/dL, respectively. MCD was diagnosed, and the patient achieved complete remission after cessation of rifampicin without undergoing steroid therapy.
Publisher: Korea (South): Yonsei University College of Medicine
Language: English
Identifier: ISSN: 0513-5796
EISSN: 1976-2437
DOI: 10.3349/ymj.2015.56.2.582
PMID: 25684013
Source: KoreaMed Synapse
GFMER Free Medical Journals
MEDLINE
PubMed Central
KoreaMed Open Access
DOAJ Directory of Open Access Journals

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Rifampicin-induced minimal change disease is improved after cessation of rifampicin without steroid therapy

Copyright: Yonsei University College of Medicine 2015 2015 ;ISSN: 0513-5796 ;EISSN: 1976-2437 ;DOI: 10.3349/ymj.2015.56.2.582 ;PMID: 25684013

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