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Antimicrobial usage in pig production: Effects on Escherichia coli virulence profiles and antimicrobial resistance

Onderstepoort journal of veterinary research, 2019-10, Vol.86 (1), p.e1-e11 [Peer Reviewed Journal]

COPYRIGHT 2019 African Online Scientific Information Systems (Pty) Ltd t/a AOSIS ;2019. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2019. The Authors 2019 ;This work is licensed under a Creative Commons Attribution 4.0 International License. ;ISSN: 0030-2465 ;ISSN: 2219-0635 ;EISSN: 2219-0635 ;DOI: 10.4102/ojvr.v86i1.1743 ;PMID: 31714139

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Title:
Antimicrobial usage in pig production: Effects on Escherichia coli virulence profiles and antimicrobial resistance
Author: Abubakar, Rukayya H ; Madoroba, Evelyn ; Adebowale, Oluwawemimo ; Fasanmi, Olubunmi G ; Fasina, Folorunso O
Subjects: Agriculture, Dairy & Animal Science ; Amoxicillin ; Anatomy & Morphology ; Animal Husbandry ; Animals ; Anti-Infective Agents - therapeutic use ; Antibacterial agents ; Antibiotics ; antimicrobial ; Antimicrobial agents ; Antimicrobial resistance ; Bacteria ; Biochemistry & Molecular Biology ; Diarrhea ; Disease ; Drug resistance ; Drug Resistance, Bacterial - genetics ; E coli ; Edema ; Enterotoxin 1 ; Enterotoxins ; Epidemics ; Escherichia coli ; Escherichia coli - drug effects ; Escherichia coli - genetics ; Escherichia coli - physiology ; Escherichia coli Infections - epidemiology ; Escherichia coli Infections - microbiology ; Escherichia coli Infections - veterinary ; Farm buildings ; Female ; Florfenicol ; Genes ; Genetic aspects ; Hogs ; Infections ; Intestines - microbiology ; Laboratory animals ; Microbial drug resistance ; Microbial Sensitivity Tests - veterinary ; Multidrug resistance ; Original Research ; Oxytetracycline ; Penicillins ; Pharmacology & Pharmacy ; Physiology ; Polymerase chain reaction ; Polymerase Chain Reaction - veterinary ; Pork industry ; Prevalence ; Random Allocation ; Shiga toxin ; Sus scrofa ; Swine ; Swine Diseases - epidemiology ; Swine Diseases - microbiology ; Tetracyclines ; Thermal stability ; Toxins ; Trimethoprim ; Veterinary Sciences ; Virulence ; Virulence (Microbiology) ; Virulence - genetics ; Weaning
Is Part Of: Onderstepoort journal of veterinary research, 2019-10, Vol.86 (1), p.e1-e11
Description: Antimicrobials (AM) are used for growth promotion and therapy in pig production. Its misuse has led to the development of resistant organisms. We evaluated Escherichia coli virulence genes, and compared phenotypic-genotypic antimicrobial resistance (AMR) patterns of faecal E. coli from pigs receiving routine farm treatment without antimicrobial agents against pigs treated routinely with AM over 70 days. Recovered E. coli were tested for AMR using disk diffusion and polymerase chain reaction. Virulence genes were detected in 24.8% of isolates from antimicrobial group and 43.5% from non-antimicrobial group (p = 0.002). The proportion of virulence genes heat-stable enterotoxins a b (STa, STb), enteroaggregative heat stable enterotoxin 1 [EAST1] and Shiga toxin type 2e [Stx2e]) were 18.1%, 0.0%, 78.7% and 3.0% for antimicrobial group and 14.8%, 8.5%, 85.1% and 12.7% for non-antimicrobial groups, respectively. Resistance to oxytetracycline was most common (p = 0.03) in samples collected between days 10 and 21. Resistance shifted to amoxicillin on days 56-70, and trimethoprim resistance was observed throughout. Seventeen phenotypic AMR combinations were observed and eight were multidrug resistant. At least one tetracycline resistance gene was found in 63.9% of the isolates. tet (A) (23.3%) was most common in the antimicrobial group, whereas tet (B) (43.5%) was prevalent in the non-antimicrobial group. Usage or non-usage of antimicrobial agents in growing pigs does not preclude virulence genes development and other complex factors may be involved as previously described. Heavily used AM correspond to the degree of resistance and tetracycline resistance genes were detected during the growth phase.
Publisher: South Africa: African Online Scientific Information Systems (Pty) Ltd t/a AOSIS
Language: English;Portuguese
Identifier: ISSN: 0030-2465
ISSN: 2219-0635
EISSN: 2219-0635
DOI: 10.4102/ojvr.v86i1.1743
PMID: 31714139
Source: SciELO
AOSIS OpenJournals
MEDLINE
ProQuest Databases
PubMed Central
DOAJ Directory of Open Access Journals

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Antimicrobial usage in pig production: Effects on Escherichia coli virulence profiles and antimicrobial resistance

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