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Non-alcoholic fatty liver disease and mortality among US adults: prospective cohort study

BMJ, 2011-11, Vol.343 (7836), p.1245-1245 [Peer Reviewed Journal]

Lazo et al 2011 ;Copyright: 2011 © Lazo et al 2011 ;Lazo et al 2011 2011 Lazo et al ;ISSN: 0959-8138 ;ISSN: 0959-8146 ;EISSN: 1468-5833 ;EISSN: 1756-1833 ;DOI: 10.1136/bmj.d6891 ;PMID: 22102439 ;CODEN: BMJOAE

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Title:
Non-alcoholic fatty liver disease and mortality among US adults: prospective cohort study
Author: Lazo, Mariana ; Hernaez, Ruben ; Bonekamp, Susanne ; Kamel, Ihab R ; Brancati, Frederick L ; Guallar, Eliseo ; Clark, Jeanne M
Subjects: Adult ; Adults ; Aged ; Alcohol use ; Algorithms ; Cancer ; Cardiovascular disease ; Cardiovascular diseases ; Confidence Intervals ; Death ; Diabetes ; Disease models ; Disease risk ; Drugs: Cardiovascular System ; Enzymes ; Epidemiologic Studies ; Epidemiology ; Fatty liver ; Fatty Liver - diagnosis ; Fatty Liver - mortality ; Female ; Follow-Up Studies ; Health risk assessment ; Humans ; Laboratories ; Liver ; Liver cancer ; Liver Disease ; Liver diseases ; Liver Function Tests ; Male ; Middle Aged ; Mortality ; Multivariate Analysis ; Non-alcoholic Fatty Liver Disease ; Nutrition ; Population studies ; Prevalence ; Proportional Hazards Models ; Prospective Studies ; Research Design ; Risk Assessment ; Risk Factors ; Rodents ; Sampling Studies ; Steatosis ; United States - epidemiology ; Womens health
Is Part Of: BMJ, 2011-11, Vol.343 (7836), p.1245-1245
Description: Objective To evaluate the association between non-alcoholic fatty liver disease and all cause and cause specific mortality in a representative sample of the US general population.Design Prospective cohort study.Setting US Third National Health and Nutrition Examination Survey (NHANES III: 1988-94) with follow-up of mortality to 2006.Participants 11 371 adults aged 20-74 participating in the Third National Health and Nutrition Examination Survey, with assessment of hepatic steatosis.Main outcome measure Mortality from all causes, cardiovascular disease, cancer, and liver disease (up to 18 years of follow-up).Results The prevalence of non-alcoholic fatty liver disease with and without increased levels of liver enzymes in the population was 3.1% and 16.4%, respectively. Compared with participants without steatosis, those with non-alcoholic fatty liver disease but normal liver enzyme levels had multivariate adjusted hazard ratios for deaths from all causes of 0.92 (95% confidence interval 0.78 to 1.09), from cardiovascular disease of 0.86 (0.67 to 1.12), from cancer of 0.92 (0.67 to 1.27), and from liver disease of 0.64 (0.12 to 3.59). Compared with participants without steatosis, those with non-alcoholic fatty liver disease and increased liver enzyme levels had adjusted hazard ratios for deaths from all causes of 0.80 (0.52 to 1.22), from cardiovascular disease of 0.59 (0.29 to 1.20), from cancer of 0.53 (0.26 to 1.10), and from liver disease of 1.17 (0.15 to 8.93).Conclusions Non-alcoholic fatty liver disease was not associated with an increased risk of death from all causes, cardiovascular disease, cancer, or liver disease.
Publisher: England: British Medical Journal Publishing Group
Language: English
Identifier: ISSN: 0959-8138
ISSN: 0959-8146
EISSN: 1468-5833
EISSN: 1756-1833
DOI: 10.1136/bmj.d6891
PMID: 22102439
CODEN: BMJOAE
Source: BMJ Open Access Journals
AUTh Library subscriptions: ProQuest Central
MEDLINE
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Non-alcoholic fatty liver disease and mortality among US adults: prospective cohort study

Lazo et al 2011 ;Copyright: 2011 © Lazo et al 2011 ;Lazo et al 2011 2011 Lazo et al ;ISSN: 0959-8138 ;ISSN: 0959-8146 ;EISSN: 1468-5833 ;EISSN: 1756-1833 ;DOI: 10.1136/bmj.d6891 ;PMID: 22102439 ;CODEN: BMJOAE

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