Language:

Impact of inflammation on epigenetic DNA methylation – a novel risk factor for cardiovascular disease?

Journal of internal medicine, 2007-05, Vol.261 (5), p.488-499 [Peer Reviewed Journal]

2007 INIST-CNRS ;ISSN: 0954-6820 ;EISSN: 1365-2796 ;DOI: 10.1111/j.1365-2796.2007.01777.x ;PMID: 17444888

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Impact of inflammation on epigenetic DNA methylation – a novel risk factor for cardiovascular disease?
Author: Stenvinkel, P. ; Karimi, M. ; Johansson, S. ; Axelsson, J. ; Suliman, M. ; Lindholm, B. ; Heimbürger, O. ; Barany, P. ; Alvestrand, A. ; Nordfors, L. ; Qureshi, A. R. ; Ekström, T. J. ; Schalling, M.
Subjects: Biological and medical sciences ; Biomarkers - blood ; Cardiovascular Diseases - genetics ; Cardiovascular Diseases - metabolism ; Cardiovascular Diseases - mortality ; Chronic Disease ; chronic kidney disease ; DNA Methylation ; DNA-Cytosine Methylases - analysis ; DNA-Cytosine Methylases - metabolism ; Epidemiology ; Epigenesis, Genetic - genetics ; Female ; Folic Acid - blood ; General aspects ; homocysteine ; Homocysteine - blood ; Humans ; inflammation ; Inflammation - genetics ; Inflammation - metabolism ; interleukin‐6 ; Kidney Diseases - genetics ; Kidney Diseases - metabolism ; Kidney Diseases - mortality ; Male ; Medical sciences ; Medicin och hälsovetenskap ; Middle Aged ; Oxidative Stress - genetics ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Reproducibility of Results ; Risk Factors
Is Part Of: Journal of internal medicine, 2007-05, Vol.261 (5), p.488-499
Description: . Objective. The lifespan of dialysis patients is as short as in patients with metastatic cancer disease, mainly due to cardiovascular disease (CVD). DNA methylation is an important cellular mechanism modulating gene expression associated with ageing, inflammation and atherosclerotic processes. Design. DNA methylation was analysed in peripheral blood leucocytes from three different groups of chronic kidney disease (CKD) populations (37 CKD stages 3 and 4 patients, 98 CKD stage 5 patients and 20 prevalent haemodialysis patients). Thirty‐six healthy subjects served as controls. Clinical characteristics (diabetes mellitus, nutritional status and presence of clinical CVD), inflammation and oxidative stress biomarkers, homocysteine and global DNA methylation in peripheral blood leucocytes (defined as HpaII/MspI ratio by the Luminometric Methylation Assay method) were evaluated. CKD stage 5 patients (n = 98) starting dialysis treatment were followed for a period of 36 ± 2 months. Results. Inflamed patients had lower ratios of HpaII/MspI, indicating global DNA hypermethylation. Analysis by the Cox regression model demonstrated that DNA hypermethylation (HpaII/MspI ratio
Publisher: Oxford, UK: Blackwell Publishing Ltd
Language: English
Identifier: ISSN: 0954-6820
EISSN: 1365-2796
DOI: 10.1111/j.1365-2796.2007.01777.x
PMID: 17444888
Source: IngentaConnect Free/Open Access Journals
MEDLINE
Alma/SFX Local Collection

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Impact of inflammation on epigenetic DNA methylation – a novel risk factor for cardiovascular disease?

2007 INIST-CNRS ;ISSN: 0954-6820 ;EISSN: 1365-2796 ;DOI: 10.1111/j.1365-2796.2007.01777.x ;PMID: 17444888

Searching Remote Databases, Please Wait