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The role of intestinal microbiota in cardiovascular disease

Journal of cellular and molecular medicine, 2019-04, Vol.23 (4), p.2343-2350 [Peer Reviewed Journal]

2019 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. ;2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 1582-1838 ;EISSN: 1582-4934 ;DOI: 10.1111/jcmm.14195 ;PMID: 30712327

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Title:
The role of intestinal microbiota in cardiovascular disease
Author: Jin, Mengchao ; Qian, Zhiyuan ; Yin, Jiayu ; Xu, Weiting ; Zhou, Xiang
Subjects: Atherosclerosis ; Bacteria ; Bile Acids and Salts - metabolism ; Blood pressure ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - complications ; Cardiovascular Diseases - drug therapy ; Cardiovascular Diseases - microbiology ; Chemical compounds ; Cholesterol ; Congestive heart failure ; Coronary artery ; Coronary artery disease ; Coronary vessels ; Diet ; Digestive system ; Digestive tract ; Dysbacteriosis ; Dysbiosis - complications ; Dysbiosis - drug therapy ; Dysbiosis - microbiology ; Fatty acids ; Fatty Acids - metabolism ; Flora ; Gastrointestinal Microbiome - drug effects ; heart failure ; Heart Failure - complications ; Heart Failure - drug therapy ; Heart Failure - microbiology ; Humans ; Hypertension ; Hypertension - complications ; Hypertension - drug therapy ; Hypertension - metabolism ; Hypertension - microbiology ; Indican - metabolism ; intestinal microbiota ; Intestinal microflora ; Intestine ; Metabolism ; Metabolites ; Methylamines - metabolism ; Microbiota ; Microflora ; Microorganisms ; Nutrition research ; Pathogenesis ; Pharmaceuticals ; Probiotics - therapeutic use ; Review ; Reviews ; Signal transduction ; Signal Transduction - drug effects ; Sulfates ; Trimethylamine
Is Part Of: Journal of cellular and molecular medicine, 2019-04, Vol.23 (4), p.2343-2350
Description: Accumulating evidence has indicated that intestinal microbiota is involved in the development of various human diseases, including cardiovascular diseases (CVDs). In the recent years, both human and animal experiments have revealed that alterations in the composition and function of intestinal flora, recognized as gut microflora dysbiosis, can accelerate the progression of CVDs. Moreover, intestinal flora metabolizes the diet ingested by the host into a series of metabolites, including trimethylamine N‐oxide, short chain fatty acids, secondary bile acid and indoxyl sulfate, which affects the host physiological processes by activation of numerous signalling pathways. The aim of this review was to summarize the role of gut microbiota in the pathogenesis of CVDs, including coronary artery disease, hypertension and heart failure, which may provide valuable insights into potential therapeutic strategies for CVD that involve interfering with the composition, function and metabolites of the intestinal flora.
Publisher: England: John Wiley & Sons, Inc
Language: English
Identifier: ISSN: 1582-1838
EISSN: 1582-4934
DOI: 10.1111/jcmm.14195
PMID: 30712327
Source: Journals@Ovid Open Access Journal Collection Rolling
MEDLINE
PubMed Central
Wiley Blackwell Open Access Titles
ProQuest Central
DOAJ Directory of Open Access Journals

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The role of intestinal microbiota in cardiovascular disease

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