Language:

Association between CD8+ T‐cell subsets and cardiovascular disease

Journal of internal medicine, 2013-07, Vol.274 (1), p.41-51 [Peer Reviewed Journal]

2013 The Association for the Publication of the Journal of Internal Medicine ;2013 The Association for the Publication of the Journal of Internal Medicine. ;ISSN: 0954-6820 ;ISSN: 1365-2796 ;EISSN: 1365-2796 ;DOI: 10.1111/joim.12038 ;PMID: 23356723

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Association between CD8+ T‐cell subsets and cardiovascular disease
Author: Kolbus, D. ; Ljungcrantz, I. ; Andersson, L. ; Hedblad, B. ; Fredrikson, G. N. ; Björkbacka, H. ; Nilsson, J.
Subjects: Aged ; Biomarkers - blood ; Cardiac and Cardiovascular Systems ; Cardiovascular Diseases - immunology ; Carotid Intima-Media Thickness ; Carotid Stenosis - diagnostic imaging ; Carotid Stenosis - epidemiology ; Carotid Stenosis - immunology ; Carotid Stenosis - physiopathology ; CD56 Antigen - analysis ; CD8+ T cell ; CD8-Positive T-Lymphocytes - immunology ; Clinical Medicine ; Cohort Studies ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - epidemiology ; Coronary Artery Disease - immunology ; Coronary Artery Disease - physiopathology ; cytokines ; Cytokines - secretion ; Female ; Flow Cytometry ; Humans ; Incidence ; Interleukin-2 Receptor alpha Subunit - analysis ; Kaplan-Meier Estimate ; Kardiologi ; Klinisk medicin ; Leukocytes - immunology ; Male ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Middle Aged ; myocardial infarction ; Odds Ratio ; Predictive Value of Tests ; Proportional Hazards Models ; Prospective Studies ; Registries ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; stroke ; Stroke - diagnostic imaging ; Stroke - epidemiology ; Stroke - immunology ; Stroke - physiopathology ; Sweden - epidemiology
Is Part Of: Journal of internal medicine, 2013-07, Vol.274 (1), p.41-51
Description: Background The findings of experimental studies suggest that the immune system plays a key role in atherosclerosis, but the clinical importance of different immune cells in cardiovascular disease remains poorly characterized. In this study we investigated the association between CD8+ T cells and carotid disease as well as development of cardiovascular disease events. Methods The study cohort comprised 700 subjects from the cardiovascular arm of the Malmö Diet and Cancer Study. Peripheral blood mononuclear cells, obtained at the 1991–1994 baseline investigation and stored at −140 °C, were thawed and the different CD8+ T‐cell populations analysed by flow cytometry. Baseline carotid intima–media thickness and stenosis were assessed by ultrasonography and clinical events were monitored through validated national registers. Results Subjects with a high fraction of CD8+ T cells were characterized by decreased cytokine release from activated leucocytes, metabolic signs of insulin resistance and increased incidence of coronary events; hazard ratios (95% confidence intervals) for the second and third tertiles of CD8+ T cells were 2.57 (1.16, 5.67) and 2.61 (1.19, 5,71), respectively, in a Cox proportional hazards regression model. Correlations were found between the fraction of CD8+CD25+ T cells and the degree of carotid stenosis (r = 0.11, P < 0.01), and between the CD8+CD56−IFN‐γ+ T‐cell fraction and the degree of stenosis (r = −0.18, P < 0.005). The association between CD8+CD56−IFN‐γ+ T cells and carotid stenosis remained significant after controlling for major cardiovascular disease risk factors. Conclusion This study provides prospective clinical evidence for a role of CD8+ T cells in cardiovascular disease and suggests the existence of CD8+ T‐cell subsets with different pathological functions.
Publisher: England
Language: English
Identifier: ISSN: 0954-6820
ISSN: 1365-2796
EISSN: 1365-2796
DOI: 10.1111/joim.12038
PMID: 23356723
Source: IngentaConnect Free/Open Access Journals
MEDLINE

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Association between CD8+ T‐cell subsets and cardiovascular disease

2013 The Association for the Publication of the Journal of Internal Medicine ;2013 The Association for the Publication of the Journal of Internal Medicine. ;ISSN: 0954-6820 ;ISSN: 1365-2796 ;EISSN: 1365-2796 ;DOI: 10.1111/joim.12038 ;PMID: 23356723

Searching Remote Databases, Please Wait