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Diabetes and Wound Angiogenesis

International journal of molecular sciences, 2017-07, Vol.18 (7), p.1419 [Peer Reviewed Journal]

2017 by the authors. 2017 ;ISSN: 1422-0067 ;EISSN: 1422-0067 ;DOI: 10.3390/ijms18071419 ;PMID: 28671607

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  • Title:
    Diabetes and Wound Angiogenesis
  • Author: Okonkwo, Uzoagu A ; DiPietro, Luisa A
  • Subjects: angiogenesis ; Animals ; Blood Vessels - pathology ; diabetes ; Diabetes Mellitus - pathology ; Diabetes Mellitus - therapy ; Humans ; Neovascularization, Physiologic ; Review ; Wound Healing
  • Is Part Of: International journal of molecular sciences, 2017-07, Vol.18 (7), p.1419
  • Description: Diabetes Mellitus Type II (DM2) is a growing international health concern with no end in sight. Complications of DM2 involve a myriad of comorbidities including the serious complications of poor wound healing, chronic ulceration, and resultant limb amputation. In skin wound healing, which has definite, orderly phases, diabetes leads to improper function at all stages. While the etiology of chronic, non-healing diabetic wounds is multi-faceted, the progression to a non-healing phenotype is closely linked to poor vascular networks. This review focuses on diabetic wound healing, paying special attention to the aberrations that have been described in the proliferative, remodeling, and maturation phases of wound angiogenesis. Additionally, this review considers therapeutics that may offer promise to better wound healing outcomes.
  • Publisher: Switzerland: MDPI
  • Language: English
  • Identifier: ISSN: 1422-0067
    EISSN: 1422-0067
    DOI: 10.3390/ijms18071419
    PMID: 28671607
  • Source: MEDLINE
    ProQuest Databases
    PubMed Central
    DOAJ Directory of Open Access Journals
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