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Role of Extracellular Matrix in Development and Cancer Progression

International journal of molecular sciences, 2018-10, Vol.19 (10), p.3028 [Peer Reviewed Journal]

2018 by the authors. 2018 ;ISSN: 1422-0067 ;EISSN: 1422-0067 ;DOI: 10.3390/ijms19103028 ;PMID: 30287763

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Title:
Role of Extracellular Matrix in Development and Cancer Progression
Author: Walker, Cameron ; Mojares, Elijah ; Del Río Hernández, Armando
Subjects: Animals ; cancer progression ; Carcinogenesis - metabolism ; Carcinogenesis - pathology ; Epithelial-Mesenchymal Transition ; extracellular matrix ; Extracellular Matrix - metabolism ; Extracellular Matrix - pathology ; fibrosis ; Humans ; matrix remodelling ; Review ; Tumor Microenvironment ; tumour microenvironment
Is Part Of: International journal of molecular sciences, 2018-10, Vol.19 (10), p.3028
Description: The immense diversity of extracellular matrix (ECM) proteins confers distinct biochemical and biophysical properties that influence cell phenotype. The ECM is highly dynamic as it is constantly deposited, remodelled, and degraded during development until maturity to maintain tissue homeostasis. The ECM's composition and organization are spatiotemporally regulated to control cell behaviour and differentiation, but dysregulation of ECM dynamics leads to the development of diseases such as cancer. The chemical cues presented by the ECM have been appreciated as key drivers for both development and cancer progression. However, the mechanical forces present due to the ECM have been largely ignored but recently recognized to play critical roles in disease progression and malignant cell behaviour. Here, we review the ways in which biophysical forces of the microenvironment influence biochemical regulation and cell phenotype during key stages of human development and cancer progression.
Publisher: Switzerland: MDPI
Language: English
Identifier: ISSN: 1422-0067
EISSN: 1422-0067
DOI: 10.3390/ijms19103028
PMID: 30287763
Source: MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Role of Extracellular Matrix in Development and Cancer Progression

2018 by the authors. 2018 ;ISSN: 1422-0067 ;EISSN: 1422-0067 ;DOI: 10.3390/ijms19103028 ;PMID: 30287763

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