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The Role of mTOR Signaling as a Therapeutic Target in Cancer

International journal of molecular sciences, 2021-02, Vol.22 (4), p.1743 [Peer Reviewed Journal]

2021 by the authors. 2021 ;ISSN: 1422-0067 ;ISSN: 1661-6596 ;EISSN: 1422-0067 ;DOI: 10.3390/ijms22041743 ;PMID: 33572326

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  • Title:
    The Role of mTOR Signaling as a Therapeutic Target in Cancer
  • Author: Popova, Nadezhda V ; Jücker, Manfred
  • Subjects: AKT ; cancer ; mTOR ; mutation ; PI3K ; Review ; therapy
  • Is Part Of: International journal of molecular sciences, 2021-02, Vol.22 (4), p.1743
  • Description: The aim of this review was to summarize current available information about the role of phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling in cancer as a potential target for new therapy options. The mTOR and PI3K/AKT/mTORC1 (mTOR complex 1) signaling are critical for the regulation of many fundamental cell processes including protein synthesis, cell growth, metabolism, survival, catabolism, and autophagy, and deregulated mTOR signaling is implicated in cancer, metabolic dysregulation, and the aging process. In this review, we summarize the information about the structure and function of the mTOR pathway and discuss the mechanisms of its deregulation in human cancers including genetic alterations of PI3K/AKT/mTOR pathway components. We also present recent data regarding the PI3K/AKT/mTOR inhibitors in clinical studies and the treatment of cancer, as well the attendant problems of resistance and adverse effects.
  • Publisher: Switzerland: MDPI
  • Language: English
  • Identifier: ISSN: 1422-0067
    ISSN: 1661-6596
    EISSN: 1422-0067
    DOI: 10.3390/ijms22041743
    PMID: 33572326
  • Source: PubMed Central (Open access)
    AUTh Library subscriptions: ProQuest Central
    DOAJ Directory of Open Access Journals
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