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Historical Evolution and Provider Awareness of Inactive Ingredients in Oral Medications

Pharmaceutical research, 2020-12, Vol.37 (12), p.234-234, Article 234 [Peer Reviewed Journal]

Springer Science+Business Media, LLC, part of Springer Nature 2020 ;COPYRIGHT 2020 Springer ;Springer Science+Business Media, LLC, part of Springer Nature 2020. ;ISSN: 0724-8741 ;EISSN: 1573-904X ;DOI: 10.1007/s11095-020-02953-2 ;PMID: 33123783

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  • Title:
    Historical Evolution and Provider Awareness of Inactive Ingredients in Oral Medications
  • Author: Reker, Daniel ; Blum, Steven M. ; Wade, Peter ; Steiger, Christoph ; Traverso, Giovanni
  • Subjects: Biochemistry ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedicine ; Data mining ; Health care industry ; Ingredients ; Medical Law ; Medical personnel ; Oral medication ; Pharmacology/Toxicology ; Pharmacy ; Precision medicine ; Prescription writing ; Research Paper
  • Is Part Of: Pharmaceutical research, 2020-12, Vol.37 (12), p.234-234, Article 234
  • Description: Purpose A multitude of different versions of the same medication with different inactive ingredients are currently available. It has not been quantified how this has evolved historically. Furthermore, it is unknown whether healthcare professionals consider the inactive ingredient portion when prescribing medications to patients. Methods We used data mining to track the number of available formulations for the same medication over time and correlate the number of available versions in 2019 to the number of manufacturers, the years since first approval, and the number of prescriptions. A focused survey among healthcare professionals was conducted to query their consideration of the inactive ingredient portion of a medication when writing prescriptions. Results The number of available versions of a single medication have dramatically increased in the last 40 years. The number of available, different versions of medications are largely determined by the number of manufacturers producing this medication. Healthcare providers commonly do not consider the inactive ingredient portion when prescribing a medication. Conclusions A multitude of available versions of the same medications provides a potentially under-recognized opportunity to prescribe the most suitable formulation to a patient as a step towards personalized medicine and mitigate potential adverse events from inactive ingredients.
  • Publisher: New York: Springer US
  • Language: English
  • Identifier: ISSN: 0724-8741
    EISSN: 1573-904X
    DOI: 10.1007/s11095-020-02953-2
    PMID: 33123783
  • Source: ProQuest Central
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