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Finding the Optimal Resistance Training Intensity for Your Bones: Protocol for a Randomized Controlled Trial

Physical therapy, 2023-10, Vol.103 (10), p.1 [Peer Reviewed Journal]

The Author(s) 2023. Published by Oxford University Press on behalf of the American Physical Therapy Association. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2023 ;COPYRIGHT 2023 Oxford University Press ;The Author(s) 2023. Published by Oxford University Press on behalf of the American Physical Therapy Association. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com ;ISSN: 0031-9023 ;ISSN: 1538-6724 ;EISSN: 1538-6724 ;DOI: 10.1093/ptj/pzad120

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  • Title:
    Finding the Optimal Resistance Training Intensity for Your Bones: Protocol for a Randomized Controlled Trial
  • Author: Giangregorio, Lora M ; Bleakney, Robert R ; Brien, Sheila ; Butcher, Scotty J ; Chan, Brian C F ; Chilibeck, Philip D ; Devries, Michaela C ; Funnell, Larry ; Jain, Ravi ; Keller, Heather H ; Milligan, James ; Mourtzakis, Marina ; O’Hare, Bonny S ; Thabane, Lehana ; Cheung, Angela M
  • Subjects: Bones ; Care and treatment ; Clinical trials ; Comparative analysis ; Density ; Ethylenediaminetetraacetic acid ; Exercise therapy ; Falls (Accidents) ; Fractures ; Glucose metabolism ; Health aspects ; Middle aged persons ; Osteoporosis ; Physiological aspects ; Postmenopausal women ; Strength training ; Testing ; Weight training
  • Is Part Of: Physical therapy, 2023-10, Vol.103 (10), p.1
  • Description: Abstract Objective The purpose of this trial is to evaluate the effect of twice-weekly, moderate-to-high intensity progressive resistance training (PRT) for 1 year on lumbar spine bone mineral density (BMD) in individuals with low BMD, compared to attention control. Secondary analyses will examine if resistance training improves other health outcomes; if high intensity is more effective than moderate intensity resistance training for all outcomes; the cost of intervention versus benefit; the willingness to pay; and harms. Methods For this study, 324 men or postmenopausal women aged ≥50 years with a femoral neck, total hip, or lumbar spine BMD T-score of ≤−1, or a Fracture Risk Assessment Tool probability of ≥20% for major osteoporotic fracture or ≥ 3% for hip fracture are being recruited to participate in a randomized controlled trial with 1:1:1 randomization. Participants will be stratified by site (3 centers) to twice-weekly, supervised PRT at moderate intensity (about 10 repetitions maximum), to high intensity PRT (≤6 repetitions maximum), or to a home posture and balance exercise program (attention control) for 1 year (resistance training to comparator allocation ratio of 2:1). The primary outcome is lumbar spine BMD via dual-energy X-ray absorptiometry. Secondary outcomes include trabecular bone score, proximal femur and total hip BMD and structure, bone-free and appendicular lean mass, physical functioning, falls, fractures, glucose metabolism, cost per life-year gained, adverse events, and quality of life. Between-group differences will be tested in intention-to-treat and per-protocol analyses using analysis of covariance, chi-square tests, or negative binomial or logistic regression, adjusting for site and baseline values. Impact The Finding the Optimal Resistance Training Intensity For Your Bones trial will support decision making on resistance training for people at risk of fracture.
  • Publisher: Washington: Oxford University Press
  • Language: English
  • Identifier: ISSN: 0031-9023
    ISSN: 1538-6724
    EISSN: 1538-6724
    DOI: 10.1093/ptj/pzad120
  • Source: Alma/SFX Local Collection
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