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Usefullnes of atherogenic indices and Ca-LDL level to predict subclinical atherosclerosis in patients with psoriatic arthritis?

Advances in rheumatology (London, England), 2019-11, Vol.59 (1), p.49-49, Article 49 [Peer Reviewed Journal]

2019. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. ;This work is licensed under a Creative Commons Attribution 4.0 International License. ;ISSN: 2523-3106 ;EISSN: 2523-3106 ;DOI: 10.1186/s42358-019-0096-2 ;PMID: 31727163

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Title:
Usefullnes of atherogenic indices and Ca-LDL level to predict subclinical atherosclerosis in patients with psoriatic arthritis?
Author: Tecer, Duygu ; Sunar, Ismihan ; Ozdemirel, Ali Erhan ; Tural, Rabia ; Kucuksahin, Orhan ; Sepici Dincel, Aylin ; Ataman, Sebnem
Subjects: Amyloid ; Arteriosclerosis ; Arthritis ; Atherogenic indexes ; Atherosclerosis ; Biomarkers ; Body mass index ; Ca-LDL ; Cardiovascular disease ; Cardiovascular diseases ; Carotid artery ; Carotid intima-media thickness ; Cholesterol ; Glucose ; Heart attacks ; Heart failure ; High density lipoprotein ; Homeostasis ; Hypertension ; Insulin ; Insulin resistance ; Liver diseases ; Low density lipoprotein ; Metabolism ; Patients ; Plasma ; Proteins ; Psoriatic arthritis ; RHEUMATOLOGY ; Risk factors ; Standard deviation ; Stroke ; Tumor necrosis factor-TNF
Is Part Of: Advances in rheumatology (London, England), 2019-11, Vol.59 (1), p.49-49, Article 49
Description: To investigate the link between carbamylated low-density lipoprotein (ca-LDL), atherogenic index of plasma (AIP), atherogenic coefficient (AC), Castelli's risk indices I and II (CRI I and II) and subclinic atherosclerosis in psoriatic arthritis (PsA). Thirty-ninepatients and 19 age, sex, body mass index matched healthy controls were included. Insulin resistance (IR) was assessed with homeostasis of model assessment-IR (HOMA-IR). Carotid intima-media thickness (CIMT) was measured at both common carotid arteries and mean CIMT was calculated. The mean age was 49.50 ± 11.86 years and 64.1% were females in PsA group. In the PsA group, CIMT and HOMA-IR were significantly higher (p = 0.003, p = 0.043, respectively). AIP, AC, TG/HDL, CRI-1, CRI-2 and ca-LDL levels were similar between groups. In PsA group, CIMT was positively correlated with HOMA-IR, TG/HDL and AIP. Although ca-LDL was positively correlated with serum amyloid A (r = 0.744, p < 0.001), no correlation was detected between ca-LDL and CIMT (r = 0.215, p = 0.195). PsA patients with IR tended to have higher ca-LDL levels than patients without IR, but this difference lacked statistical significance (33.65 ± 26.94, 28.63 ± 28.06, respectively, p = 0.237). A significant increase in CIMT was seen in PsA patients without clinically evident cardiovascular disease or any traditional atherosclerosis risk factors. CIMT was correlated with HOMA-IR, TG/HDL and AIP.
Publisher: England: BioMed Central
Language: English;Portuguese
Identifier: ISSN: 2523-3106
EISSN: 2523-3106
DOI: 10.1186/s42358-019-0096-2
PMID: 31727163
Source: SciELO
DOAJ Directory of Open Access Journals
ProQuest Central

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Usefullnes of atherogenic indices and Ca-LDL level to predict subclinical atherosclerosis in patients with psoriatic arthritis?

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