Language:

Novel Subclone of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 with Enhanced Virulence and Transmissibility, China

Emerging infectious diseases, 2020-02, Vol.26 (2), p.289-297 [Peer Reviewed Journal]

COPYRIGHT 2020 U.S. National Center for Infectious Diseases ;COPYRIGHT 2020 U.S. National Center for Infectious Diseases ;Published 2020. This article is a U.S. Government work and is in the public domain in the USA. ;ISSN: 1080-6040 ;EISSN: 1080-6059 ;DOI: 10.3201/eid2602.190594 ;PMID: 31961299

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Novel Subclone of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 with Enhanced Virulence and Transmissibility, China
Author: Zhou, Kai ; Xiao, Tingting ; David, Sophia ; Wang, Qin ; Zhou, Yanzi ; Guo, Lihua ; Aanensen, David ; Holt, Kathryn E ; Thomson, Nicholas R ; Grundmann, Hajo ; Shen, Ping ; Xiao, Yonghong
Subjects: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - therapeutic use ; Bacterial pneumonia ; carbapenem resistance ; Carbapenem-Resistant Enterobacteriaceae - drug effects ; Carbapenem-Resistant Enterobacteriaceae - isolation & purification ; China ; China - epidemiology ; Chinese history ; Cloning ; Diversification ; Drug Resistance, Multiple, Bacterial ; Female ; Genomes ; Health aspects ; Humans ; Imipenem ; Infection ; Infections ; Klebsiella Infections - drug therapy ; Klebsiella Infections - epidemiology ; Klebsiella Infections - mortality ; Klebsiella Infections - prevention & control ; Klebsiella pneumoniae ; Klebsiella pneumoniae - drug effects ; Klebsiella pneumoniae - genetics ; Klebsiella pneumoniae - isolation & purification ; Klebsiella pneumoniae - pathogenicity ; Male ; Medical Records ; Meropenem ; Microbial Sensitivity Tests ; Middle Aged ; Mortality ; Novel Subclone of Carbapenem-Resistant ; Patients ; Phylogenetics ; Phylogeny ; Pneumonia ; Population ; Prevalence ; recombination ; Retrospective Studies ; Sequence Type 11 with Enhanced Virulence and Transmissibility, China ; ST11 ; subclonal shift ; Survival Analysis ; Tigecycline ; Virulence ; Young Adult
Is Part Of: Emerging infectious diseases, 2020-02, Vol.26 (2), p.289-297
Description: We aimed to clarify the epidemiologic and clinical importance of evolutionary events that occurred in carbapenem-resistant Klebsiella pneumoniae (CRKP). We collected 203 CRKP causing bloodstream infections in a tertiary hospital in China during 2013-2017. We detected a subclonal shift in the dominant clone sequence type (ST) 11 CRKP in which the previously prevalent capsular loci (KL) 47 had been replaced by KL64 since 2016. Patients infected with ST11-KL64 CRKP had a significantly higher 30-day mortality rate than other CRKP-infected patients. Enhanced virulence was further evidenced by phenotypic tests. Phylogenetic reconstruction demonstrated that ST11-KL64 is derived from an ST11-KL47-like ancestor through recombination. We identified a pLVPK-like virulence plasmid carrying rmpA and peg-344 in ST11-KL64 exclusively from 2016 onward. The pLVPK-like-positive ST11-KL64 isolates exhibited enhanced environmental survival. Retrospective screening of a national collection identified ST11-KL64 in multiple regions. Targeted surveillance of this high-risk CRKP clone is urgently needed.
Publisher: United States: U.S. National Center for Infectious Diseases
Language: English
Identifier: ISSN: 1080-6040
EISSN: 1080-6059
DOI: 10.3201/eid2602.190594
PMID: 31961299
Source: Centers for Disease Control and Prevention
U.S. Government Documents
GFMER Free Medical Journals
MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Novel Subclone of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 with Enhanced Virulence and Transmissibility, China

COPYRIGHT 2020 U.S. National Center for Infectious Diseases ;COPYRIGHT 2020 U.S. National Center for Infectious Diseases ;Published 2020. This article is a U.S. Government work and is in the public domain in the USA. ;ISSN: 1080-6040 ;EISSN: 1080-6059 ;DOI: 10.3201/eid2602.190594 ;PMID: 31961299

Searching Remote Databases, Please Wait