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1 alpha,25-Dihydroxyvitamin D3 decreases scalding- and platelet-activating factor-induced high vascular permeability and tissue oedema
Pharmacology & toxicology, 1995-06, Vol.76 (6), p.365
ISSN: 0901-9928 ;PMID: 7479576
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Title:
1 alpha,25-Dihydroxyvitamin D3 decreases scalding- and platelet-activating factor-induced high vascular permeability and tissue oedema
Author:
Chen, S F
;
Ruan, Y J
Subjects:
Animals
;
Burns - drug therapy
;
Burns - physiopathology
;
Calcitriol - therapeutic use
;
Capillary Permeability - drug effects
;
Edema - drug therapy
;
Edema - etiology
;
Edema - physiopathology
;
Hindlimb - blood supply
;
Hindlimb - injuries
;
Male
;
Platelet Activating Factor - adverse effects
;
Platelet Activating Factor - antagonists & inhibitors
;
Rats
;
Rats, Sprague-Dawley
Is Part Of:
Pharmacology & toxicology, 1995-06, Vol.76 (6), p.365
Description:
We have previously demonstrated that 1,25-dihydroxyvitamin D3 decreases endotoxin-induced mortalities of rat and mouse from 80% and 70% to 14% and 10% (unpublished results). In the present study, pretreatment of 1,25-dihydroxyvitamin D3 decreased pad oedema and pulmonary vascular permeability induced by scalding and platelet-activating factor. 1,25-Dihydroxyvitamin D3 in a dose of 4 x 10(-9) mol/kg decreased pulmonary extravascular Evans blue concentration increased by platelet-activating factor from 6.32 +/- 0.63 ng/g to 2.57 +/- 0.28 ng/g (P < 0.01), and lung water/dry lung weight from 3.79 +/- 0.57 to 1.51 +/- 0.13 (P < 0.01). 1,25-Dihydroxyvitamin D3 of 4 x 10(-11) moles/kg and calcipotriol (a vitamin D analogue which has limited hypercalcaemic effect) of 4 x 10(-9) moles/kg had similar effects. Karyocyte counting of bronchoalveolar lavage fluid and the reduction of mean arterial pressure were also reduced to some extent. These results suggest that 1,25-dihydroxyvitamin D3 may be a new and effective drug to reduce vascular permeability and ameliorate oedema.
Publisher:
Denmark
Language:
English
Identifier:
ISSN: 0901-9928
PMID: 7479576
Source:
MEDLINE
Alma/SFX Local Collection
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