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Enduring effects of adolescent ketamine exposure on cocaine- and sucrose-induced reward in male and female C57BL/6 mice

Neuropsychopharmacology (New York, N.Y.), 2020-08, Vol.45 (9), p.1536-1544 [Peer Reviewed Journal]

The Author(s), under exclusive licence to American College of Neuropsychopharmacology 2020. ;The Author(s), under exclusive licence to American College of Neuropsychopharmacology 2020 ;ISSN: 0893-133X ;EISSN: 1740-634X ;DOI: 10.1038/s41386-020-0654-7 ;PMID: 32165718

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  • Title:
    Enduring effects of adolescent ketamine exposure on cocaine- and sucrose-induced reward in male and female C57BL/6 mice
  • Author: Garcia-Carachure, Israel ; Flores-Ramirez, Francisco J ; Castillo, Samuel A ; Themann, Anapaula ; Arenivar, Miguel A ; Preciado-Piña, Joshua ; Zavala, Arturo R ; Lobo, Mary Kay ; Iñiguez, Sergio D
  • Subjects: Age ; Antidepressants ; Cocaine ; Experiments ; Ketamine ; Mental depression ; Phenotypes ; Place preference conditioning ; Reinforcement ; Social interactions ; Sucrose ; Teenagers
  • Is Part Of: Neuropsychopharmacology (New York, N.Y.), 2020-08, Vol.45 (9), p.1536-1544
  • Description: Ketamine has shown promising antidepressant efficacy for adolescent treatment-resistant depression. However, the potential enduring consequences of ketamine exposure have not been thoroughly evaluated. Thus, we examined if juvenile ketamine treatment results in long-lasting changes for the rewarding properties of sucrose and cocaine in adulthood, across three separate experiments. In Experiment 1, adolescent male and female C57BL/6 mice received ketamine (20 mg/kg) for 15 consecutive days (Postnatal Day [PD] 35-49). Twenty-one days later (PD70; adulthood) we examined their behavioral responsivity to sucrose (1%) on a two-bottle choice design, or cocaine (0, 5, 10 mg/kg) using the conditioned place preference (CPP) test. We found that juvenile ketamine-pretreatment increased preference for sucrose and environments paired with cocaine in male, but not female, adult mice. This long-term outcome was not observed when male and female mice received ketamine as adults (PD70-84) and tested for sucrose and cocaine preference 21-days later (Experiment 2). Similarly, in Experiment 3, no long-lasting differences in these measures were observed when adolescent male mice were exposed to concomitant ketamine and social stressors (PD35-44), namely the social defeat or vicarious defeat stress paradigms-procedures that mediated a depression-related phenotype (along with a ketamine antidepressant-like response). Collectively, we demonstrate that in the absence of physical or psychological stress, adolescent ketamine exposure increases later life preference for the rewarding properties of sucrose and cocaine in a sex- and age-specific manner. As such, this preclinical work provides awareness for the potential long-term behavioral consequences associated with juvenile ketamine exposure.
  • Publisher: England: Nature Publishing Group
  • Language: English
  • Identifier: ISSN: 0893-133X
    EISSN: 1740-634X
    DOI: 10.1038/s41386-020-0654-7
    PMID: 32165718
  • Source: ProQuest One Psychology
    PubMed Central (Open access)
    Geneva Foundation Free Medical Journals at publisher websites
    ProQuest Central
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