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Analysis of changes in the volume of edema around brain contusions and the influencing factors: A single-center, retrospective, observational study

Medicine (Baltimore), 2021-09, Vol.100 (38), p.e27246-e27246 [Peer Reviewed Journal]

Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. ;Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. 2021 ;ISSN: 0025-7974 ;EISSN: 1536-5964 ;DOI: 10.1097/MD.0000000000027246 ;PMID: 34559127

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  • Title:
    Analysis of changes in the volume of edema around brain contusions and the influencing factors: A single-center, retrospective, observational study
  • Author: Liu, Hai-Bing ; Xu, Wei-Ming ; Wang, Shou-Sen ; Wei, Liang-Feng ; Hong, Jing-Fang ; Wang, Cheng ; Xian, Liang
  • Subjects: Adult ; Brain Contusion - complications ; Brain Edema - classification ; Brain Edema - etiology ; Female ; Humans ; Male ; Middle Aged ; Observational Study ; Retrospective Studies ; Tomography, X-Ray Computed - methods
  • Is Part Of: Medicine (Baltimore), 2021-09, Vol.100 (38), p.e27246-e27246
  • Description: Traumatic brain injury (TBI), a common neurosurgical condition, has well-known treatment guidelines. However, the mechanisms underlying the varying severity of brain edema secondary to TBI are largely unknown, leading to controversial treatments.This study seeks to measure edema volumes around brain contusions in different regions, analyze factors related to differences in edema volume and provide a theoretical basis for brain edema treatment.Data from 113 brain contusion patients treated at the Department of Neurosurgery of Fuzhou General Hospital from January 2017 to November 2019 were analyzed retrospectively. Based on computed tomography (CT) data, the patients were divided into the venous group (brain contusion in regions with large cortical veins, n = 47) and the nonvenous group (brain contusions in other regions, n = 66). Here, 3D Slicer software was used to calculate the brain contusion volume on the first CT obtained after injury and the brain contusion volume and its surrounding edema on the 5th day after injury. The brain contusion volume to surrounding edema volume ratio was calculated, and the number of patients who showed brain contusion progression requiring surgery was determined. Hematocrit (Hct), fibrinogen (Fg), and d-dimer levels within 6 hours and on the 5th day after admission were also compared.Patients in the venous group had a significantly increased percentage of area with edema around the brain contusion compared with patients in the nonvenous group (P < .05), and the 2 groups showed no significant difference in the number of patients with brain contusion progression or surgical treatment (P > .05) or Hct, Fg, or d-dimer (D-D) levels. For all patients, Hct, Fg, and D-D levels within 6 hours after admission were significantly different from those on the 5th day (P < .05 for all).Cortical venous obstruction may be the most important factor influencing edema around brain contusions. The Fg level decreased slightly, and the D-D level increased to its peak rapidly after mild-moderate TBI. This change was followed by a gradual increase in the former and a gradual decrease in the latter.
  • Publisher: United States: Lippincott Williams & Wilkins
  • Language: English
  • Identifier: ISSN: 0025-7974
    EISSN: 1536-5964
    DOI: 10.1097/MD.0000000000027246
    PMID: 34559127
  • Source: Open Access: DOAJ Directory of Open Access Journals
    Journals@Ovid Open Access Journal Collection Rolling
    Wolters Kluwer Open Health
    MEDLINE
    PubMed Central
    IngentaConnect website
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