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Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study

European Respiratory Journal, 2020-05, Vol.55 (5), p.2000524 [Peer Reviewed Journal]

Copyright ©ERS 2020. ;2020. This work is licensed under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;Copyright ©ERS 2020 2020 ;ISSN: 0903-1936 ;EISSN: 1399-3003 ;DOI: 10.1183/13993003.00524-2020 ;PMID: 32269088

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Title:
Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study
Author: Du, Rong-Hui ; Liang, Li-Rong ; Yang, Cheng-Qing ; Wang, Wen ; Cao, Tan-Ze ; Li, Ming ; Guo, Guang-Yun ; Du, Juan ; Zheng, Chun-Lan ; Zhu, Qi ; Hu, Ming ; Li, Xu-Yan ; Peng, Peng ; Shi, Huan-Zhong
Subjects: Adult ; Age Distribution ; Age Factors ; Aged ; Aged, 80 and over ; Betacoronavirus ; Cardiovascular Diseases - epidemiology ; Case-Control Studies ; CD8-Positive T-Lymphocytes ; Cerebrovascular Disorders - epidemiology ; China ; Comorbidity ; Coronavirus ; Coronavirus Infections - diagnosis ; Coronavirus Infections - mortality ; COVID-19 ; Female ; Humans ; Male ; Middle Aged ; Original ; Pandemics ; Pneumonia, Viral - diagnosis ; Pneumonia, Viral - mortality ; Pneumonia, Viral - therapy ; Prospective Studies ; SARS-CoV-2 ; Troponin I - blood
Is Part Of: European Respiratory Journal, 2020-05, Vol.55 (5), p.2000524
Description: The aim of this study was to identify factors associated with the death of patients with COVID-19 pneumonia caused by the novel coronavirus SARS-CoV-2.All clinical and laboratory parameters were collected prospectively from a cohort of patients with COVID-19 pneumonia who were hospitalised to Wuhan Pulmonary Hospital (Wuhan City, Hubei Province, China) between 25 December 2019 and 7 February 2020. Univariate and multivariate logistic regression analysis revealed that age ≥65 years (OR 3.765, 95% CI 1.146–17.394; p=0.023), pre-existing concurrent cardiovascular or cerebrovascular diseases (OR 2.464, 95% CI 0.755–8.044; p=0.007), CD3+CD8+ T-cells ≤75 cells·μL−1 (OR 3.982, 95% CI 1.132–14.006; p<0.001) and cardiac troponin I ≥0.05 ng·mL−1 (OR 4.077, 95% CI 1.166–14.253; p<0.001) were associated with an increase in risk of mortality from COVID-19 pneumonia.” has been corrected to: “Univariate and multivariate logistic regression analysis revealed that age ≥65 years (OR 3.765, 95% CI 1.201−11.803; p=0.023), pre-existing concurrent cardiovascular or cerebrovascular diseases (OR 2.464, 95% CI 1.279−4.747; p=0.007), CD3+CD8+ T-cells ≤75 cells·μL−1 (OR 3.982, 95% CI 1.761–9.004; p<0.001) and cardiac troponin I ≥0.05 ng·mL−1 (OR 4.077, 95% CI 1.778–9.349; p<0.001) were associated with an increase in risk of mortality from COVID-19 pneumonia. In a sex-, age- and comorbid illness-matched case-control study, CD3 CD8 T-cells ≤75 cells·μL and cardiac troponin I ≥0.05 ng·mL remained as predictors for high mortality from COVID-19 pneumonia.We identified four risk factors: age ≥65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3 CD8 T-cells ≤75 cells·μL and cardiac troponin I ≥0.05 ng·mL The latter two factors, especially, were predictors for mortality of COVID-19 pneumonia patients.
Publisher: England: European Respiratory Society Journals Ltd
Language: English
Identifier: ISSN: 0903-1936
EISSN: 1399-3003
DOI: 10.1183/13993003.00524-2020
PMID: 32269088
Source: Coronavirus Research Database

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Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study

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