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Hemodiafiltration to Address Unmet Medical Needs ESKD Patients

Clinical journal of the American Society of Nephrology, 2018-09, Vol.13 (9), p.1435-1443 [Peer Reviewed Journal]

Copyright © 2018 by the American Society of Nephrology. ;Distributed under a Creative Commons Attribution 4.0 International License ;Copyright © 2018 by the American Society of Nephrology 2018 ;ISSN: 1555-9041 ;EISSN: 1555-905X ;DOI: 10.2215/CJN.12631117 ;PMID: 29511057

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  • Title:
    Hemodiafiltration to Address Unmet Medical Needs ESKD Patients
  • Author: Canaud, Bernard ; Vienken, Jörg ; Ash, Stephen ; Ward, Richard A
  • Subjects: Health Services Needs and Demand ; Hemodiafiltration - instrumentation ; Hemodiafiltration - methods ; Human health and pathology ; Humans ; Kidney Failure, Chronic - therapy ; Life Sciences ; Treatment Outcome ; Urology and Nephrology
  • Is Part Of: Clinical journal of the American Society of Nephrology, 2018-09, Vol.13 (9), p.1435-1443
  • Description: Hemodiafiltration combines diffusive and convective solute removal in a single therapy by ultrafiltering 20% or more of the blood volume processed using a high-flux hemodialyzer and maintaining fluid balance by infusing sterile nonpyrogenic replacement fluid directly into the patient's blood. In online hemodiafiltration, the large volumes of replacement fluid required are obtained by online filtration of standard dialysate through a series of bacteria- and endotoxin-retaining filters. Currently available systems for online hemodiafiltration are on the basis of conventional dialysis machines with added features to safely prepare and infuse replacement fluid and closely control fluid balance. Hemodiafiltration provides greater removal of higher molecular weight uremic retention solutes than conventional high-flux hemodialysis, and recently completed randomized, controlled clinical trials suggest better patient survival with online hemodiafiltration compared with standard high-flux hemodialysis when a high convection volume is delivered. Hemodiafiltration is also associated with improvements in other clinical outcomes, such as a reduction in intradialytic hypotension, and it is now used routinely to treat >100,000 patients, mainly in Europe and Japan.
  • Publisher: United States: American Society of Nephrology
  • Language: English
  • Identifier: ISSN: 1555-9041
    EISSN: 1555-905X
    DOI: 10.2215/CJN.12631117
    PMID: 29511057
  • Source: Geneva Foundation Free Medical Journals at publisher websites
    MEDLINE
    Alma/SFX Local Collection
    PubMed Central (PMC)
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