Language:

Therapeutic approaches for cardiac regeneration and repair

Nature reviews cardiology, 2018-10, Vol.15 (10), p.585-600 [Peer Reviewed Journal]

COPYRIGHT 2018 Nature Publishing Group ;Copyright Nature Publishing Group Oct 2018 ;ISSN: 1759-5002 ;EISSN: 1759-5010 ;DOI: 10.1038/s41569-018-0036-6 ;PMID: 29872165

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Therapeutic approaches for cardiac regeneration and repair
Author: Hashimoto, Hisayuki ; Olson, Eric N ; Bassel-Duby, Rhonda
Subjects: Animals ; Cardiomyocytes ; Cardiovascular disease ; Care and treatment ; Cell cycle ; Cellular therapy ; Clinical trials ; Gene therapy ; Genetic Therapy - methods ; Heart ; Heart Diseases - genetics ; Heart Diseases - pathology ; Heart Diseases - physiopathology ; Heart Diseases - therapy ; Heart failure ; Heart Ventricles - pathology ; Heart Ventricles - physiopathology ; Humans ; Methods ; Myocardial ischemia ; Myocardium - pathology ; Physiological aspects ; Recovery of Function ; Regeneration ; Regenerative medicine ; Stem Cell Transplantation - methods ; Tissue engineering ; Treatment Outcome ; Ventricular Remodeling
Is Part Of: Nature reviews cardiology, 2018-10, Vol.15 (10), p.585-600
Description: Ischaemic heart disease is a leading cause of death worldwide. Injury to the heart is followed by loss of the damaged cardiomyocytes, which are replaced with fibrotic scar tissue. Depletion of cardiomyocytes results in decreased cardiac contraction, which leads to pathological cardiac dilatation, additional cardiomyocyte loss, and mechanical dysfunction, culminating in heart failure. This sequential reaction is defined as cardiac remodelling. Many therapies have focused on preventing the progressive process of cardiac remodelling to heart failure. However, after patients have developed end-stage heart failure, intervention is limited to heart transplantation. One of the main reasons for the dramatic injurious effect of cardiomyocyte loss is that the adult human heart has minimal regenerative capacity. In the past 2 decades, several strategies to repair the injured heart and improve heart function have been pursued, including cellular and noncellular therapies. In this Review, we discuss current therapeutic approaches for cardiac repair and regeneration, describing outcomes, limitations, and future prospects of preclinical and clinical trials of heart regeneration. Substantial progress has been made towards understanding the cellular and molecular mechanisms regulating heart regeneration, offering the potential to control cardiac remodelling and redirect the adult heart to a regenerative state.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1759-5002
EISSN: 1759-5010
DOI: 10.1038/s41569-018-0036-6
PMID: 29872165
Source: MEDLINE
ProQuest Central

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Therapeutic approaches for cardiac regeneration and repair

COPYRIGHT 2018 Nature Publishing Group ;Copyright Nature Publishing Group Oct 2018 ;ISSN: 1759-5002 ;EISSN: 1759-5010 ;DOI: 10.1038/s41569-018-0036-6 ;PMID: 29872165

Searching Remote Databases, Please Wait