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NF-[kappa]B, inflammation, immunity and cancer: coming of age

Nature reviews. Immunology, 2018-05, Vol.18 (5), p.309 [Peer Reviewed Journal]

COPYRIGHT 2018 Nature Publishing Group ;COPYRIGHT 2018 Nature Publishing Group ;Copyright Nature Publishing Group May 2018 ;ISSN: 1474-1733 ;EISSN: 1474-1741 ;DOI: 10.1038/nri.2017.142

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  • Title:
    NF-[kappa]B, inflammation, immunity and cancer: coming of age
  • Author: Taniguchi, Koji ; Karin, Michael
  • Subjects: Cancer ; Carcinogenesis ; Genetic aspects ; Health aspects ; Health risks ; Immune response ; Inflammation ; Molecular chains ; NF-κB protein ; Transcription factors ; Tumors
  • Is Part Of: Nature reviews. Immunology, 2018-05, Vol.18 (5), p.309
  • Description: Fourteen years have passed since nuclear factor-[kappa]B (NF-[kappa]B) was first shown to serve as a molecular lynchpin that links persistent infections and chronic inflammation to increased cancer risk. The young field of inflammation and cancer has now come of age, and inflammation has been recognized by the broad cancer research community as a hallmark and cause of cancer. Here, we discuss how the initial discovery of a role for NF-[kappa]B in linking inflammation and cancer led to an improved understanding of tumour-elicited inflammation and its effects on anticancer immunity.
  • Publisher: London: Nature Publishing Group
  • Language: English
  • Identifier: ISSN: 1474-1733
    EISSN: 1474-1741
    DOI: 10.1038/nri.2017.142
  • Source: ProQuest Central
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