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Therapeutic effects of inhibitors of PLC and IP3R on secondary brain injury after diffuse axonal injury / PLC及IP3R拮抗剂对弥漫性轴索损伤后继发性脑损伤的治疗作用

Xi'an jiao tong da xue xue bao. Journal of Xi'an Jiaotong University (medical sciences). Yi xue ban, 2015-01 (1), p.28

Copyright Xi'an Jiaotong University 2015 ;ISSN: 1671-8259 ;DOI: 10.7652/jdyxb201501005

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  • Title:
    Therapeutic effects of inhibitors of PLC and IP3R on secondary brain injury after diffuse axonal injury / PLC及IP3R拮抗剂对弥漫性轴索损伤后继发性脑损伤的治疗作用
  • Author: LI, Yu ; Jin-ning, SONG ; ZHANG, Ming ; Ji-yang, AN ; SUN, Peng ; Dan-dong, LI ; Xu-dong, MA ; Ya-hui, ZHAO
  • Subjects: Cytotoxicity ; Edema
  • Is Part Of: Xi'an jiao tong da xue xue bao. Journal of Xi'an Jiaotong University (medical sciences). Yi xue ban, 2015-01 (1), p.28
  • Description: Objective: To investigate whether inhibitors of PLC and IP3R have therapeutic effects on neuronal degeneration and damage caused by diffuse axonal injury (DAI). Methods In vivo DAI model was established by an instant lateral head rotation device. And intracerebroventricular injection method was used for the drug administration of xestospongin C (XeC, inhibitor of IP3 receptor) and U73122 (inhibitor of PLC). Then, wet-dry weight ratio method was used to measure brain water content. ELISA was conducted to measure albumin (Alb) concentrations both in the spinal cerebral fluid (CSF) and serum, and ratio of Alb concentration in CSF to Alb concentration in the serum (QAlb) was calculated. β-APP immunohistochemistry was used to determine the degree of neuronal degeneration and injury. Western blot was applied to test whether U73122 intracerebroventricular injection suppressed the phosphorylation process of PLC. Results: The brain water content increased significantly at 6h after DAI, peaked at 24h, then gradually d
  • Publisher: Xi'an: Xi'an Jiaotong University
  • Language: Chinese
  • Identifier: ISSN: 1671-8259
    DOI: 10.7652/jdyxb201501005
  • Source: ProQuest Central
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